2026-07-23T23:05:02Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/147702024-11-30T00:05:22Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Drosten, Matthias author Barbacid, Mariano author 2020-04-13 KRAS mutations occur in a quarter of all of human cancers, yet no selective drug has been approved to treat these tumors. Despite the recent development of drugs that block KRASG12C, the majority of KRAS oncoproteins remain undruggable. Here, we review recent efforts to validate individual components of the mitogen-activated protein kinase (MAPK) pathway as targets to treat KRAS-mutant cancers by comparing genetic information derived from experimental mouse models of KRAS-driven lung and pancreatic tumors with the outcome of selective MAPK inhibitors in clinical trials. We also review the potential of RAF1 as a key target to block KRAS-mutant cancers. Cancer Cell . 2020;37(4):543-550. 10.1016/j.ccell.2020.03.013 1878-3686 1535-6108 Cancer cell 32289276 http://hdl.handle.net/20.500.12105/14770 Targeting the MAPK Pathway in KRAS-Driven Tumors.