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oai:repisalud.isciii.es:20.500.12105/147562025-04-29T09:45:32Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud author Benschop, Kimberley SM author Broberg, Eeva K author Hodcroft, Emma author Schmitz, Dennis author Albert, Jan author Baicus, Anda author Bailly, Jean-Luc author Baldvinsdottir, Gudrun author Berginc, Natasa author Blomqvist, Soile author Böttcher, Sindy author Brytting, Mia author Bujaki, Erika author Cabrerizo, Maria author Celma, Cristina author Cinek, Ondrej author Claas, Eric C J author Cremer, Jeroen author Dean, Jonathan author Dembinski, Jennifer L author Demchyshyna, Iryna author Diedrich, Sabine author Dudman, Susanne author Dunning, Jake author Dyrdak, Robert author Emmanouil, Mary author Farkas, Agnes author De Gascun, Cillian author Fournier, Guillaume author Georgieva, Irina author Gonzalez-Sanz, Ruben author van Hooydonk-Elving, Jolanda author Jääskeläinen, Anne J author Jancauskaite, Ruta author Keeren, Kathrin author Fischer, Thea K author Krokstad, Sidsel author Nikolaeva-Glomb, Lubomira author Novakova, Ludmila author Midgley, Sofie Elisabeth author Mirand, Audrey author Molenkamp, Richard author Morley, Ursula author Mossong, Joël author Muralyte, Svajune author Murk, Jean-Luc author Nguyen, Trung author Nordbø, Svein A author Österback, Riikka author Pas, Suzan author Pellegrinelli, Laura author Pogka, Vassiliki author Prochazka, Birgit author Rainetova, Petra author Van Ranst, Marc author Roorda, Lieuwe author Schuffenecker, Isabelle author Schuurman, Rob author Stoyanova, Asya author Templeton, Kate author Verweij, Jaco J author Voulgari-Kokota, Androniki author Vuorinen, Tytti author Wollants, Elke author Wolthers, Katja C author Zakikhany, Katherina author Neher, Richard author Harvala, Heli author Simmonds, Peter funder Ministry of Health Welfare and Sport (Países Bajos) funder Unión Europea. Comisión Europea. H2020 funder Wellcome Trust funder Aristotle University of Thessaloniki (Grecia) funder National Institute for Health and Disability Insurance (Bélgica) 2022-07-20T11:54:42Z 2022-07-20T11:54:42Z 2021-06 Emerg Infect Dis. 2021 Jun;27(6):1616-1626. 10.3201/eid2706.203096 1080-6059 Emerging Infectious Diseases 34013874 http://hdl.handle.net/20.500.12105/14756 In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected persons 0-4 years of age (29%) and 25-34 years of age (27%). Sequences were divided into 6 genetic clades (G1-G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections. eng Europe European Non-Polio Enterovirus Network Molecular epidemiology Nextstrain; echovirus 30 Enterovirus Epidemiological monitoring Evolutionary trajectory Genetic recombination Meningitis/encephalitis Neurological manifestations Viruses Whole-genome sequencing Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe research article 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 URL https://repisalud.isciii.es/bitstreams/fb6edb6d-7a4d-431b-b2e2-cdb72ad7a264/download File MD5 bacae6e1f69a811c2ea9e871ddd476df 4441386 application/pdf MolecularEpidemiologyAndEvolutionary_2021.pdf URL https://repisalud.isciii.es/bitstreams/9e936931-9f2b-44fd-9e72-412dd1999561/download File MD5 2c1057070a396a6244dfcf84912ac3c3 52990 text/plain MolecularEpidemiologyAndEvolutionary_2021.pdf.txt