2026-06-14T03:32:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/145522024-11-29T10:43:41Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16978
Repisalud
author
Rodríguez-Izquierdo, Ignacio
author
Sepulveda-Crespo, Daniel
author
Lasso, Jose María
author
Resino, Salvador
author
Muñoz-Fernández, María Ángeles
funder
Instituto de Salud Carlos III
funder
Plan Nacional de I+D+i (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Economía y Competitividad (España)
funder
Gordon and Betty Moore Foundation
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
funder
Unión Europea. European Cooperation in Science and Technology (COST)
2022-05-26T11:46:43Z
2022-05-26T11:46:43Z
2022-05
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 May;14(3):e1774.
10.1002/wnan.1774
1939-0041
Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
35018739
http://hdl.handle.net/20.500.12105/14552
Although a wide variety of topical microbicides provide promising in vitro and in vivo efficacy, most of them failed to prevent sexual transmission of human immunodeficiency virus type 1 (HIV-1) in human clinical trials. In vitro, ex vivo, and in vivo models must be optimized, considering the knowledge acquired from unsuccessful and successful clinical trials to improve the current gaps and the preclinical development protocols. To date, dendrimers are the only nanotool that has advanced to human clinical trials as topical microbicides to prevent HIV-1 transmission. This fact demonstrates the importance and the potential of these molecules as microbicides. Polyanionic dendrimers are highly branched nanocompounds with potent activity against HIV-1 that disturb HIV-1 entry. Herein, the most significant advancements in topical microbicide development, trying to mimic the real-life conditions as closely as possible, are discussed. This review also provides the preclinical assays that anionic dendrimers have passed as microbicides because they can improve current antiviral treatments' efficacy.
eng
HIV-1
Acceptability
Dendrimer
Preclinical steps
Regulation
Vaginal microbicide
Baseline and time-updated factors in preclinical development of anionic dendrimers as successful anti-HIV-1 vaginal microbicides
journal article
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URL
https://repisalud.isciii.es/bitstreams/96bd9f5a-101b-436b-8838-e300670e5c20/download
File
MD5
2dd0975a7ec4852d8b04a56998ddcdd2
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application/pdf
BaselineTimeUpdatedFactors_2022.pdf
URL
https://repisalud.isciii.es/bitstreams/626cfc46-9734-4e9e-b815-cef25b4986cc/download
File
MD5
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text/plain
BaselineTimeUpdatedFactors_2022.pdf.txt