2026-06-14T00:34:53Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/145232025-05-09T09:12:24Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19613

00925njm 22002777a 4500 dc Ayala, Alba author Triviño-Juárez, José-Matías author Forjaz, Maria João author Rodriguez-Blazquez, Carmen author Rojo-Abuin, Jose Manuel author Martínez-Martín, Pablo author ELEP Project author 2017-10-30 Objective: The aim of this study is to present a predictive model of Parkinson's disease (PD) global severity, measured with the Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD). Methods: This is an observational, longitudinal study with annual follow-up assessments over 3 years (four time points). A multilevel analysis and multiple imputation techniques were performed to generate a predictive model that estimates changes in the CISI-PD at 1, 2, and 3 years. Results: The clinical state of patients (CISI-PD) significantly worsened in the 3-year follow-up. However, this change was of small magnitude (effect size: 0.44). The following baseline variables were significant predictors of the global severity change: baseline global severity of disease, levodopa equivalent dose, depression and anxiety symptoms, autonomic dysfunction, and cognitive state. The goodness-of-fit of the model was adequate, and the sensitive analysis showed that the data imputation method applied was suitable. Conclusion: Disease progression depends more on the individual's baseline characteristics than on the 3-year time period. Results may contribute to a better understanding of the evolution of PD including the non-motor manifestations of the disease. Front Neurol. 2017 Oct 30;8:551. 10.3389/fneur.2017.00551 1664-2295 Frontiers in Neurology 29163328 http://hdl.handle.net/20.500.12105/14523 Parkinson’s disease Disease global severity Multilevel analysis Multiple imputation Predictive model Parkinson's Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baseline