2026-07-23T23:02:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/144832024-11-29T10:02:29Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16977
Repisalud
author
Álvarez, Beatriz
author
Navarrete-Muñoz, María A
author
Briz, Veronica
author
Olmedillas-López, Susana
author
Nistal, Sara
author
Cabello, Alfonso
author
Prieto, Laura
author
Górgolas, Miguel
author
García-Arranz, Mariano
author
Benito, José Miguel
author
Rallón, Norma
funder
Instituto de Salud Carlos III
funder
Plan Nacional de I+D+i (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
2022-05-24T10:20:14Z
2022-05-24T10:20:14Z
2022-03-24
Sci Rep. 2022 Mar 24;12(1):5095.
10.1038/s41598-022-08871-0
2045-2322
Scientific Reports
35332180
http://hdl.handle.net/20.500.12105/14483
The role of HCV on the HIV reservoir is controversial since the reduction on HIV-DNA levels after HCV eradication with IFNα/RBV treatment seems to be the result of drugs instead of HCV clearance. We assessed whether HCV eradication can decrease HIV-DNA content in HIV/HCV-coinfected patients treated with direct-acting antivirals, DAAs (IFNα/RBV-free regimens). Cell-associated HIV-DNA was measured by ddPCR in 25 HIV-monoinfected and 25 HIV/HCV-coinfected patients. There were no differences in HIV-DNA levels between groups neither at baseline nor at 12 weeks after DAAs treatment completion. Our results indicate that HCV does not appear to influence the HIV reservoir size and suggest the lack of an anti-HIV action for DAAs.
eng
HIV-reservoir size is not affected either by HCV coinfection or by direct acting antivirals (DAAs) therapy
journal article
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URL
https://repisalud.isciii.es/bitstreams/156864e3-d9f9-4d41-8155-69cb6202b8a3/download
File
MD5
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application/pdf
HIVReservoirSizeNot_2022.pdf
URL
https://repisalud.isciii.es/bitstreams/2bbf88cb-c372-4076-8c95-37911264ee6e/download
File
MD5
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text/plain
HIVReservoirSizeNot_2022.pdf.txt