2026-05-22T00:03:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/144752025-04-24T18:08:59Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16961
Repisalud
author
Garcia-Vidal, Carolina
author
Iglesias-Caballero, Maria
author
Puerta-Alcalde, Pedro
author
Mas-Lloret, Vicente
author
Cuesta-Chasco, Genoveva
author
Garcia-Pouton, Nicole
author
Varona Fernandez, Sarai
author
Pozo Sanchez, Francisco
author
Vázquez-Morón, Sonia
author
Marcos, María Ángeles
author
Soriano, Alex
author
Casas Flecha, Inmaculada
author
HEMATOCOVID19-Researchers Group
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Sanidad (España)
funder
Hospital Clínic de Barcelona
2022-05-24T08:25:52Z
2022-05-24T08:25:52Z
2022-03-03
Front Microbiol. 2022 Mar 3;13:826883.
10.3389/fmicb.2022.826883
1664-302X
Frontiers in Microbiology
35308337
http://hdl.handle.net/20.500.12105/14475
We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino acids and 29 in nucleotides. Some of these changes, such as the E484Q, were mutations of concern as defined by WHO. This finding represents an enormous epidemiological threat and poses a major clinical challenge. Combined antiviral strategies, as well as specific strategies related to the diagnostic approach of prolonged infections for this specific population, may be needed.
eng
COVID-19
Antivirals
Hematology
Immunosuppression
Mutations
Persistence
Remdesivir
Emergence of Progressive Mutations in SARS-CoV-2 From a Hematologic Patient With Prolonged Viral Replication
research article
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