2026-06-30T02:01:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/144662024-11-29T11:48:32Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16984
Repisalud
author
Mancebo, Francisco Jose
author
Parras-Moltó, Marcos
author
Garcia-Rios, Estefani
author
Perez-Romero, Pilar
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Instituto de Salud Carlos III
funder
Swedish Research Council
2022-05-23T14:44:11Z
2022-05-23T14:44:11Z
2022-03-02
Int J Mol Sci. 2022 Mar 2;23(5):2768.
10.3390/ijms23052768
1422-0067
International Journal of Molecular Sciences
35269907
http://hdl.handle.net/20.500.12105/14466
CMV is a major cause of morbidity and mortality in immunocompromised individuals that will benefit from the availability of a vaccine. Despite the efforts made during the last decade, no CMV vaccine is available. An ideal CMV vaccine should elicit a broad immune response against multiple viral antigens including proteins involved in virus-cell interaction and entry. However, the therapeutic use of neutralizing antibodies targeting glycoproteins involved in viral entry achieved only partial protection against infection. In this scenario, a better understanding of the CMV proteome potentially involved in viral entry may provide novel candidates to include in new potential vaccine design. In this study, we aimed to explore the CMV genome to identify proteins with putative transmembrane domains to identify new potential viral envelope proteins. We have performed in silico analysis using the genome sequences of nine different CMV strains to predict the transmembrane domains of the encoded proteins. We have identified 77 proteins with transmembrane domains, 39 of which were present in all the strains and were highly conserved. Among the core proteins, 17 of them such as UL10, UL139 or US33A have no ascribed function and may be good candidates for further mechanistic studies.
eng
Cytomegalovirus
Pangenome
Proteome
Transmembrane.
Deciphering the Potential Coding of Human Cytomegalovirus: New Predicted Transmembrane Proteome
journal article
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