2026-06-14T01:09:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/144522024-09-27T21:56:49Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Lopez, Daniel
funder
Instituto de Salud Carlos III
2022-05-23T10:21:19Z
2022-05-23T10:21:19Z
2022-01-28
Front Immunol. 2022 Jan 28;13:832889.
10.3389/fimmu.2022.832889
1664-3224
Frontiers in Immunology
35154154
http://hdl.handle.net/20.500.12105/14452
The potential effect of emerging SARS-CoV-2 variants on vaccine efficacy is an issue of critical importance. In this study, the possible impact of mutations that facilitate virus escape from the cytotoxic and the helper cellular immune responses in the new SARS-CoV-2 Omicron variant of concern was analyzed for the 551 and 41 most abundant HLA class I and II alleles, respectively. Computational prediction showed that almost all of these 592 alleles, which cover >90% of the human population, contain enough epitopes without escape mutations in the emerging SARS-CoV-2 Omicron variant of concern. These data suggest that both cytotoxic and helper cellular immune protection elicited by currently licensed vaccines are virtually unaffected by the highly contagious SARS-CoV-2 Omicron variant of concern.
eng
HLA class 1
HLA class 2
SARS-CoV-2
Escape mutant
Vaccine
Predicted HLA Class I and Class II Epitopes From Licensed Vaccines Are Largely Conserved in New SARS-CoV-2 Omicron Variant of Concern
journal article
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