2026-04-29T12:23:40Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/144432024-09-27T20:31:41Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Martin-Vicente, Maria author Resino, Salvador author Martinez, Isidoro author 2022-02-13 The human respiratory syncytial virus (HRSV) causes severe lower respiratory tract infections in infants and the elderly. An exuberant inadequate immune response is behind most of the pathology caused by the HRSV. The main targets of HRSV infection are the epithelial cells of the respiratory tract, where the immune response against the virus begins. This early innate immune response consists of the expression of hundreds of pro-inflammatory and anti-viral genes that stimulates subsequent innate and adaptive immunity. The early innate response in infected cells is mediated by intracellular signaling pathways composed of pattern recognition receptors (PRRs), adapters, kinases, and transcriptions factors. These pathways are tightly regulated by complex networks of post-translational modifications, including ubiquitination. Numerous ubiquitinases and deubiquitinases make these modifications reversible and highly dynamic. The intricate nature of the signaling pathways and their regulation offers the opportunity for fine-tuning the innate immune response against HRSV to control virus replication and immunopathology. J Biomed Sci. 2022 Feb 13;29(1):11. 10.1186/s12929-022-00793-3 1423-0127 Journal of Biomedical Science 35152905 http://hdl.handle.net/20.500.12105/14443 Immune Response Regulation Innate immunity Respiratory Syncytial Virus Ubiquitination Early innate immune response triggered by the human respiratory syncytial virus and its regulation by ubiquitination/deubiquitination processes