2026-08-29T14:55:22Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/143502024-09-27T20:10:42Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Martin-Galiano, Antonio Javier
author
Díez-Fuertes, Francisco
author
McConnell, Michael J
author
Lopez, Daniel
funder
Instituto de Salud Carlos III
2022-05-09T13:00:50Z
2022-05-09T13:00:50Z
2021-11
Front Immunol. 2021 Nov 25;12:732693.
10.3389/fimmu.2021.732693
1664-3224
Frontiers in Immunology
34899692
http://hdl.handle.net/20.500.12105/14350
The effect of emerging SARS-CoV-2 variants on vaccine efficacy is of critical importance. In this study, the potential impact of mutations that facilitate escape from the cytotoxic cellular immune response in these new virus variants for the 551 most abundant HLA class I alleles was analyzed. Computational prediction showed that most of these alleles, that cover >90% of the population, contain enough epitopes without escape mutations in the principal SARS-CoV-2 variants. These data suggest that the cytotoxic cellular immune protection elicited by vaccination is not greatly affected by emerging SARS-CoV-2 variants.
eng
HLA
SARS-CoV-2
T cell epitope
Epidemic
Escape mutant
Vaccine
Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
journal article
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PredictedEpitopeAbundanceSupports_2021.pdf
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PredictedEpitopeAbundanceSupports_2021.pdf.txt