2026-08-29T14:55:40Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/143502024-09-27T20:10:42Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Martin-Galiano, Antonio Javier author Díez-Fuertes, Francisco author McConnell, Michael J author Lopez, Daniel author 2021-11 The effect of emerging SARS-CoV-2 variants on vaccine efficacy is of critical importance. In this study, the potential impact of mutations that facilitate escape from the cytotoxic cellular immune response in these new virus variants for the 551 most abundant HLA class I alleles was analyzed. Computational prediction showed that most of these alleles, that cover >90% of the population, contain enough epitopes without escape mutations in the principal SARS-CoV-2 variants. These data suggest that the cytotoxic cellular immune protection elicited by vaccination is not greatly affected by emerging SARS-CoV-2 variants. Front Immunol. 2021 Nov 25;12:732693. 10.3389/fimmu.2021.732693 1664-3224 Frontiers in Immunology 34899692 http://hdl.handle.net/20.500.12105/14350 HLA SARS-CoV-2 T cell epitope Epidemic Escape mutant Vaccine Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern