2026-06-14T05:07:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/143352025-05-05T13:32:14Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19613
Repisalud
author
Schwarz, Christine
author
Pedraza-Flechas, Ana Maria
author
Pastor-Barriuso, Roberto
author
Lope Carvajal, Virginia
author
Fernandez de Larrea-Baz, Nerea
author
Jimenez-Moleon, Jose J.
author
Pollan-Santamaria, Marina
author
Perez-Gomez, Beatriz
2022-05-09T11:11:04Z
2022-05-09T11:11:04Z
2021-11
Cancers (Basel). 2021 Nov 26;13(23):5952.
10.3390/cancers13235952
2072-6694
Cancers
34885062
http://hdl.handle.net/20.500.12105/14335
This systematic review discusses long-term NSW and female BC risk, with special attention to differences between pre- and postmenopausal BC, to test the association with recent NSW. The review follows PRISMA guidelines (Prospero registry: CRD42018102515). We searched PubMed, Embase, and WOS for case-control, nested case-control, and cohort studies addressing long-term NSW (≥15 years) as risk exposure and female BC as outcome until 31 December 2020. Risk of bias was evaluated with the Newcastle-Ottawa scale. Eighteen studies were finally included (eight cohorts; five nested case-control; five case-control). We performed meta-analyses on long-term NSW and BC risk; overall and by menopausal status; a subanalysis on recent long-term NSW, based on studies involving predominantly women below retirement age; and a dose-response meta-analysis on NSW duration. The pooled estimate for long-term NSW and BC was 1.13 (95%CI = 1.01-1.27; 18 studies, I2 = 56.8%, p = 0.002). BC risk increased 4.7% per 10 years of NSW (95%CI = 0.94-1.09; 16 studies, I2 = 33.4%, p = 0.008). The pooled estimate for premenopausal BC was 1.27 (95%CI = 0.96-1.68; six studies, I2 = 32.0%, p = 0.196) and for postmenopausal BC 1.05 (95%CI = 0.90-1.24,I2 = 52.4%; seven studies, p = 0.050). For recent long-term exposure, the pooled estimate was 1.23 (95%CI = 1.06-1.42; 15 studies; I2 = 48.4%, p = 0.018). Our results indicate that long-term NSW increases the risk for BC and that menopausal status and time since exposure might be relevant.
eng
Breast cancer
Menopausal status
Meta-analysis
Nightshift work
Occupational exposure
Recent exposure
Retirement age
Long-Term Nightshift Work and Breast Cancer Risk: An Updated Systematic Review and Meta-Analysis with Special Attention to Menopausal Status and to Recent Nightshift Work
research article
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LongTermNightshiftWork_2021.pdf
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LongTermNightshiftWorkSupplementaryMaterial_2021.pdf
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https://repisalud.isciii.es/bitstreams/0fc0707c-06c1-4ebc-8b56-60223b303f8c/download
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LongTermNightshiftWork_2021.pdf.txt
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https://repisalud.isciii.es/bitstreams/5f2d67cf-a5c6-41ab-903e-5fbb4d3fc351/download
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LongTermNightshiftWorkSupplementaryMaterial_2021.pdf.txt