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00925njm 22002777a 4500 dc Schlosser, Pascal author Tin, Adrienne author Matias-Garcia, Pamela R author Thio, Chris H. L. author Joehanes, Roby author Liu, Hongbo author Weihs, Antoine author Yu, Zhi author Hoppmann, Anselm author Grundner-Culemann, Franziska author Min, Josine L author Adeyemo, Adebowale A author Agyemang, Charles author Ärnlöv, Johan author Aziz, Nasir A author Baccarelli, Andrea author Bochud, Murielle author Brenner, Hermann author Breteler, Monique M B author Carmeli, Cristian author Chaker, Layal author Chambers, John C author Cole, Shelley A author Coresh, Josef author Corre, Tanguy author Correa, Adolfo author Cox, Simon R author de Klein, Niek author Delgado, Graciela E author Domingo-Relloso, Arce author Eckardt, Kai-Uwe author Ekici, Arif B. author Endlich, Karlhans author Evans, Kathryn L author Floyd, James S author Fornage, Myriam author Franke, Lude author Fraszczyk, Eliza author Gao, Xu author Gào, Xīn author Ghanbari, Mohsen author Ghasemi, Sahar author Gieger, Christian author Greenland, Philip author Grove, Megan L author Harris, Sarah E author Hemani, Gibran author Henneman, Peter author Herder, Christian author Horvath, Steve author Hou, Lifang author Hurme, Mikko A author Hwang, Shih-Jen author Jarvelin, Marjo-Riitta author Kardia, Sharon L R author Kasela, Silva author Kleber, Marcus E author Koenig, Wolfgang author Kooner, Jaspal S author Kramer, Holly author Kronenberg, Florian author Kühnel, Brigitte author Lehtimäki, Terho author Lind, Lars author Liu, Dan author Liu, Yongmei author Lloyd-Jones, Donald M author Lohman, Kurt author Lorkowski, Stefan author Lu, Ake T. author Marioni, Riccardo E author März, Winfried author McCartney, Daniel L author Meeks, Karlijn A. C. author Milani, Lili author Mishra, Pashupati P author Nauck, Matthias author Navas-Acien, Ana author Nowak, Christoph author Peters, Annette author Prokisch, Holger author Psaty, Bruce M author Raitakari, Olli T author Ratliff, Scott M author Reiner, Alex P author Rosas, Sylvia E author Schöttker, Ben author Schwartz, Joel author Sedaghat, Sanaz author Smith, Jennifer A author Sotoodehnia, Nona author Stocker, Hannah R author Stringhini, Silvia author Sundström, Johan author Swenson, Brenton R author Tellez-Plaza, Maria author van Meurs, Joyce B J author van Vliet-Ostaptchouk, Jana V author Venema, Andrea author Verweij, Niek author Walker, Rosie M author Wielscher, Matthias author Winkelmann, Juliane author Wolffenbuttel, Bruce H. R. author Zhao, Wei author Zheng, Yinan author Loh, Marie author Snieder, Harold author Levy, Daniel author Waldenberger, Melanie author Susztak, Katalin author Köttgen, Anna author Teumer, Alexander author Estonian Biobank Research Team author Genetics of DNA Methylation Consortium author 2021-12 Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs. Nat Commun. 2021 Dec 9;12(1):7174. http://hdl.handle.net/20.500.12105/14334 34887417 10.1038/s41467-021-27234-3 2041-1723 Nature Communications Chronic kidney disease DNA methylation Epidemiology Translational research Meta-analyses identify DNA methylation associated with kidney function and damage