2026-06-14T00:29:51Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/143232024-09-27T16:34:02Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19609col_20.500.12105_19613
Repisalud
author
Perez-Gomez, Beatriz
author
Pastor-Barriuso, Roberto
author
Perez-Olmeda, Mayte
author
Hernán, Miguel A
author
Oteo-Iglesias, Jesus
author
Fernandez de Larrea-Baz, Nerea
author
Fernandez-Garcia, Aurora
author
Martín, Mariano
author
Fernandez-Navarro, Pablo L
author
Cruz, Israel
author
Sanmartín, Jose L
author
Paniagua-Caparros, Jose Leon
author
Muñoz-Montalvo, Juan F
author
Blanco, Faustino
author
Yotti-Alvarez, Raquel
author
Pollan-Santamaria, Marina
author
ENE-COVID Study Group
funder
Instituto de Salud Carlos III
funder
Ministerio de Sanidad (España)
2022-05-09T09:07:31Z
2022-05-09T09:07:31Z
2021-11
J Clin Epidemiol. 2021 Nov;139:240-254.
10.1016/j.jclinepi.2021.06.005
1878-5921
Journal of Clinical Epidemiology
34126206
http://hdl.handle.net/20.500.12105/14323
Objectives: To characterize asymptomatic SARS-CoV-2 infections and develop a symptom-based risk score useful in primary healthcare. Study design and setting: Sixty-one thousand ninty-two community-dwelling participants in a nationwide population-based serosurvey completed a questionnaire on COVID-19 symptoms and received an immunoassay for SARS-CoV-2 IgG antibodies between April 27 and June 22, 2020. Standardized prevalence ratios for asymptomatic infection were estimated across participant characteristics. We constructed a symptom-based risk score and evaluated its ability to predict SARS-CoV-2 infection. Results: Of all, 28.7% of infections were asymptomatic (95% CI 26.1-31.4%). Standardized asymptomatic prevalence ratios were 1.19 (1.02-1.40) for men vs. women, 1.82 (1.33-2.50) and 1.45 (0.96-2.18) for individuals <20 and ≥80 years vs. those aged 40-59, 1.27 (1.03-1.55) for smokers vs. nonsmokers, and 1.91 (1.59-2.29) for individuals without vs. with case contact. In symptomatic population, a symptom-based score (weights: severe tiredness = 1; absence of sore throat = 1; fever = 2; anosmia/ageusia = 5) reached standardized seroprevalence ratio of 8.71 (7.37-10.3), discrimination index of 0.79 (0.77-0.81), and sensitivity and specificity of 71.4% (68.1-74.4%) and 74.2% (73.1-75.2%) for a score ≥3. Conclusion: The presence of anosmia/ageusia, fever with severe tiredness, or fever without sore throat should serve to suspect COVID-19 in areas with active viral circulation. The proportion of asymptomatics in children and adolescents challenges infection control.
eng
COVID-19
General population
Nationwide serosurvey
Prediction model
SARS-CoV-2 infection
Symptoms
ENE-COVID nationwide serosurvey served to characterize asymptomatic infections and to develop a symptom-based risk score to predict COVID-19
research article
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ENECOVIDNationwideSerosurvey_2021.pdf
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ENECOVIDNationwideSerosurvey_2021.pdf.txt
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