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00925njm 22002777a 4500 dc Martínez-Horta, Saul author Bejr-Kasem, Helena author Horta-Barba, Andrea author Pascual-Sedano, Berta author Santos-García, Diego author de Deus-Fonticoba, Teresa author Jesús, Silvia author Aguilar, Miquel author Planellas, Lluis author García-Caldentey, Juan author Caballol, Nuria author Vives-Pastor, Bárbara author Hernández-Vara, Jorge author Cabo-Lopez, Iria author López-Manzanares, Lydia author González-Aramburu, Isabel author Ávila-Rivera, Maria Asunción author Catalán, Maria Jose author López-Díaz, Luis Manuel author Puente, Victor author García-Moreno, Jose Manuel author Borrué, Carmen author Solano-Vila, Berta author Álvarez-Sauco, Maria author Vela, Lydia author Escalante, Sonia author Cubo, Esther author Carrillo-Padilla, Francisco author Martínez-Castrillo, Juan Carlos author Sánchez-Alonso, Pilar author Alonso-Losada, Maria Gema author López-Ariztegui, Nuria author Gastón, Itziar author Blázquez-Estrada, Marta author Seijo-Martínez, Manuel author Rúiz-Martínez, Javier author Valero-Merino, Caridad author Kurtis, Mónica M author de Fábregues-Boixar, Oriol author González-Ardura, Jessica author Prieto-Jurczynska, Cristina author Martínez-Martín, Pablo author Mir, Pablo author Kulisevsky, Jaime author COPPADIS Study Group author 2021-12 Background:Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results:Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p < 0.05) and cognitive stimulation (< 0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p < 0.05), Il6 (p < 0.05), iron (p < 0.05), and homocysteine (p < 0.005) levels, and positively associated with vitamin B12 levels (p < 0.005). Conclusions: We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD. BMC Neurol. 2021 Dec 8;21(1):477. 10.1186/s12883-021-02485-1 1471-2377 BMC Neurology 34879838 http://hdl.handle.net/20.500.12105/14320 Cognition Coppadis Lifestyle PD-MCI Parkinson’s disease Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease