2026-08-29T09:17:20Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/143152025-04-22T11:57:41Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16962

00925njm 22002777a 4500 dc Fernández-Delgado, Lucía author Càmara, Jordi author González-Díaz, Aida author Grau, Inmaculada author Shoji, Hisashi author Tubau, Fe author Martí, Sara author Domínguez, María Ángeles author Carratalà, Jordi author Yuste, Jose Enrique author Ardanuy, Carmen author 2021-10-28 We studied changes in serotype distribution and antimicrobial susceptibility in adult pneumococcal pneumonia in Spain (2011-2019). Among 895 pneumococci collected (433 bacteremic [BPP] and 462 non-bacteremic [non-BPP]), serotypes 3 (17%), 19A (10%), 8 (6.7%) and 11A (6.7%) were the most frequent. Serotypes 16F, 19A and 24F were associated with old people (≥65) and serotypes 4, 7F, 8, 12F and 19F to young adults. Serotypes 12F, 24F and 1 were significantly more frequent in BPP and serotypes 11A, 23A and 19F in non-BPP. Amoxicillin resistance was higher in non-BPP (17% vs. 11%) while penicillin non-susceptibility (37% vs. 24%) and macrolide resistance (29% vs. 14%) were higher in older adults. In the period 2017-2019, the vaccine coverages were: 32% (PCV13), 39% (PCV15), 65% (PCV20) and 69% (PPV23). Differences were found in serotype composition and antimicrobial resistance by age and type of infection. The maintenance of serotype 3 as a leading cause of adult pneumococcal pneumonia and the increase in highly invasive (serotype 8) or antimicrobial-resistant (serotype 11A) serotypes is worrisome. Further studies will be required to analyse the impact of the upcoming broader conjugate vaccines. Microorganisms. 2021 Oct 28;9(11):2245. 10.3390/microorganisms9112245 2076-2607 Microorganisms 34835371 http://hdl.handle.net/20.500.12105/14315 Streptococcus pneumoniae Antimicrobial resistance Pneumococcal conjugate vaccines (PCVs) Pneumonia Serotype Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines