2026-07-21T21:47:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/143142025-06-24T16:01:01Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_19609col_20.500.12105_16968
Repisalud
author
Domínguez, Angela
author
Varela Martinez, Maria del Carmen
author
Soldevila, Núria
author
Izquierdo, Conchita
author
Guerrero-Vadillo, María
author
Peñuelas, Marina
author
Martínez, Ana
author
Godoy, Pere
author
Borràs, Eva
author
Rius, Cristina
author
Torner, Núria
author
Avellón, Ana
author
Castilla Catalán, Jesús
author
PREVICET Working Group on Viral Hepatitis
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)
2022-05-09T07:12:44Z
2022-05-09T07:12:44Z
2021-10-20
Vaccines (Basel). 2021 Oct 20;9(11):1214.
10.3390/vaccines9111214
2076-393X
Vaccines
34835145
http://hdl.handle.net/20.500.12105/14314
We compared the cumulative incidence and characteristics of hepatitis A outbreaks in two groups of Spanish autonomous regions according to whether a universal or risk group vaccination strategy was followed. Outbreaks between 2010 and 2018 were analyzed. The cumulative incidence rate of outbreaks was estimated and compared by estimating the rate ratio (RR). The characteristics of the outbreaks and those of the first cases were compared. Adjusted OR (aOR) were calculated using a multivariate logistic regression model. Outbreak incidence was 16.04 per million persons in regions with universal vaccination and 20.76 in those with risk-group vaccination (RR 0.77; 95%CI 0.62-0.94). Imported outbreaks accounted for 65% in regions with universal vaccination and 28.7% in regions with risk-group vaccination (aOR 3.88; 95%CI 2.13-7.09). Adolescents and young adults aged 15-44 years and men who have sex with men were less frequently the first case of the outbreak in regions with a universal vaccination strategy (aOR 0.54; 95%CI 0.32-0.92 and 0.23; 95%CI 0.07-0.82, respectively). The cumulative incidence rate of outbreaks was lower in regions with universal vaccination. In all regions, independently of the vaccination strategy, activities to vaccinate persons belonging to high-risk groups for infection should be emphasized.
eng
Hepatitis A
Outbreak
Risk groups
Transmission
Vaccination strategy
Hepatitis A Outbreak Characteristics: A Comparison of Regions with Different Vaccination Strategies, Spain 2010-2018
research article
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