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oai:repisalud.isciii.es:20.500.12105/143142025-06-24T16:01:01Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_19609col_20.500.12105_16968

00925njm 22002777a 4500 dc Domínguez, Angela author Varela Martinez, Maria del Carmen author Soldevila, Núria author Izquierdo, Conchita author Guerrero-Vadillo, María author Peñuelas, Marina author Martínez, Ana author Godoy, Pere author Borràs, Eva author Rius, Cristina author Torner, Núria author Avellón, Ana author Castilla Catalán, Jesús author PREVICET Working Group on Viral Hepatitis author 2021-10-20 We compared the cumulative incidence and characteristics of hepatitis A outbreaks in two groups of Spanish autonomous regions according to whether a universal or risk group vaccination strategy was followed. Outbreaks between 2010 and 2018 were analyzed. The cumulative incidence rate of outbreaks was estimated and compared by estimating the rate ratio (RR). The characteristics of the outbreaks and those of the first cases were compared. Adjusted OR (aOR) were calculated using a multivariate logistic regression model. Outbreak incidence was 16.04 per million persons in regions with universal vaccination and 20.76 in those with risk-group vaccination (RR 0.77; 95%CI 0.62-0.94). Imported outbreaks accounted for 65% in regions with universal vaccination and 28.7% in regions with risk-group vaccination (aOR 3.88; 95%CI 2.13-7.09). Adolescents and young adults aged 15-44 years and men who have sex with men were less frequently the first case of the outbreak in regions with a universal vaccination strategy (aOR 0.54; 95%CI 0.32-0.92 and 0.23; 95%CI 0.07-0.82, respectively). The cumulative incidence rate of outbreaks was lower in regions with universal vaccination. In all regions, independently of the vaccination strategy, activities to vaccinate persons belonging to high-risk groups for infection should be emphasized. Vaccines (Basel). 2021 Oct 20;9(11):1214. 10.3390/vaccines9111214 2076-393X Vaccines 34835145 http://hdl.handle.net/20.500.12105/14314 Hepatitis A Outbreak Risk groups Transmission Vaccination strategy Hepatitis A Outbreak Characteristics: A Comparison of Regions with Different Vaccination Strategies, Spain 2010-2018