2026-06-14T05:05:22Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/143112024-11-29T11:27:59Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16982
Repisalud
author
Toribio, María José
author
Priego-Capote, Feliciano
author
Perez-Gomez, Beatriz
author
Fernandez de Larrea-Baz, Nerea
author
Ruiz Moreno, Emma
author
Castelló Pastor, Adela
author
de Lucas, Maria Pilar
author
Sierra, Maria Angeles
author
Pino, Marina Nieves
author
Martínez-Cortés, Mercedes
author
Luque de Castro, María Dolores
author
Lope Carvajal, Virginia
author
Pollan-Santamaria, Marina
funder
Ministerio de Sanidad (España)
funder
Instituto de Salud Carlos III
2022-05-09T06:38:55Z
2022-05-09T06:38:55Z
2021-10-23
Nutrients. 2021;13(11):3747.
10.3390/nu13113747
2072-6643
Nutrients
34836003
http://hdl.handle.net/20.500.12105/14311
The most representative indicator of vitamin D status in clinical practice is 25(OH)D3, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39-50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE-LC-MS/MS platform. The association between participant's characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D3 concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)2D3/25(OH)D3) and a higher R4 (24,25(OH)2D3/1,25(OH)2D3) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D3/Vit D3) and R3 (24,25(OH)2D3/25(OH)D3), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes.
eng
1,25(OH)2D3
24,25(OH)2D3
25(OH)D3
Vit D3
Vitamin D metabolite ratios
Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women
journal article
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FactorsAssociatedWithSerum_2021.pdf
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FactorsAssociatedWithSerumSupplementaryMaterial_2021.pdf
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FactorsAssociatedWithSerum_2021.pdf.txt
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