2026-06-14T03:33:02Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/143112024-11-29T11:27:59Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16982

00925njm 22002777a 4500 dc Toribio, María José author Priego-Capote, Feliciano author Perez-Gomez, Beatriz author Fernandez de Larrea-Baz, Nerea author Ruiz Moreno, Emma author Castelló Pastor, Adela author de Lucas, Maria Pilar author Sierra, Maria Angeles author Pino, Marina Nieves author Martínez-Cortés, Mercedes author Luque de Castro, María Dolores author Lope Carvajal, Virginia author Pollan-Santamaria, Marina author 2021-10-23 The most representative indicator of vitamin D status in clinical practice is 25(OH)D3, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39-50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE-LC-MS/MS platform. The association between participant's characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D3 concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)2D3/25(OH)D3) and a higher R4 (24,25(OH)2D3/1,25(OH)2D3) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D3/Vit D3) and R3 (24,25(OH)2D3/25(OH)D3), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes. Nutrients. 2021;13(11):3747. 10.3390/nu13113747 2072-6643 Nutrients 34836003 http://hdl.handle.net/20.500.12105/14311 1,25(OH)2D3 24,25(OH)2D3 25(OH)D3 Vit D3 Vitamin D metabolite ratios Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women