2026-04-29T12:23:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/142922024-09-27T21:43:50Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Ruiz García, Yara
author
Sohn, Woo-Yun
author
Seib, Kate L
author
Taha, Muhamed-Kheir
author
Vazquez-Moreno, Julio Alberto
author
Silva de Lemos, Ana Paula
author
Vadivelu, Kumaran
author
Pizza, Mariagrazia
author
Rappuoli, Rino
author
Bekkat-Berkani, Rafik
funder
GlaxoSmithKline
2022-05-06T08:15:50Z
2022-05-06T08:15:50Z
2021-10-29
NPJ Vaccines 2021 Oct 29;6(1):130.
10.1038/s41541-021-00388-3
2059-0105
NPJ Vaccines
34716336
http://hdl.handle.net/20.500.12105/14292
Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80-90% genome sequence identity. The recombinant meningococcal serogroup B (MenB) vaccine 4CMenB consists of four antigenic components that can be present in non-B meningococcal and gonococcal strains. This comprehensive review summarizes scientific evidence on the genotypic and phenotypic similarities between vaccine antigens and their homologs expressed by non-B meningococcal and gonococcal strains. It also includes immune responses of 4CMenB-vaccinated individuals and effectiveness and impact of 4CMenB against these strains. Varying degrees of strain coverage were estimated depending on the non-B meningococcal serogroup and antigenic repertoire. 4CMenB elicits immune responses against non-B meningococcal serogroups and N. gonorrhoeae. Real-world evidence showed risk reductions of 69% for meningococcal serogroup W clonal complex 11 disease and 40% for gonorrhea after 4CMenB immunization. In conclusion, functional antibody activity and real-world evidence indicate that 4CMenB has the potential to provide some protection beyond MenB disease.
eng
Looking beyond meningococcal B with the 4CMenB vaccine: the Neisseria effect
journal article
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URL
https://repisalud.isciii.es/bitstreams/fc1e3e68-ecea-404f-b826-ac72fc8251e0/download
File
MD5
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application/pdf
LookingBeyondMeningococcalB_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/b3c2b373-09b6-47e0-b3af-e47b88cf3526/download
File
MD5
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text/plain
LookingBeyondMeningococcalB_2021.pdf.txt