2026-06-30T02:51:39Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/142852024-11-29T08:53:34Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16970

00925njm 22002777a 4500 dc López, Nahúm Cueto author García-Ordás, María Teresa author Vitelli-Storelli, Facundo author Fernandez-Navarro, Pablo L author Palazuelos, Camilo author Alaiz-Rodríguez, Rocío author 2021-10-12 This study evaluates several feature ranking techniques together with some classifiers based on machine learning to identify relevant factors regarding the probability of contracting breast cancer and improve the performance of risk prediction models for breast cancer in a healthy population. The dataset with 919 cases and 946 controls comes from the MCC-Spain study and includes only environmental and genetic features. Breast cancer is a major public health problem. Our aim is to analyze which factors in the cancer risk prediction model are the most important for breast cancer prediction. Likewise, quantifying the stability of feature selection methods becomes essential before trying to gain insight into the data. This paper assesses several feature selection algorithms in terms of performance for a set of predictive models. Furthermore, their robustness is quantified to analyze both the similarity between the feature selection rankings and their own stability. The ranking provided by the SVM-RFE approach leads to the best performance in terms of the area under the ROC curve (AUC) metric. Top-47 ranked features obtained with this approach fed to the Logistic Regression classifier achieve an AUC = 0.616. This means an improvement of 5.8% in comparison with the full feature set. Furthermore, the SVM-RFE ranking technique turned out to be highly stable (as well as Random Forest), whereas relief and the wrapper approaches are quite unstable. This study demonstrates that the stability and performance of the model should be studied together as Random Forest and SVM-RFE turned out to be the most stable algorithms, but in terms of model performance SVM-RFE outperforms Random Forest. Int J Environ Res Public Health. 2021 Oct 12;18(20):10670. 10.3390/ijerph182010670 1660-4601 International Journal of Environmental Research and Public Health 34682416 http://hdl.handle.net/20.500.12105/14285 Breast cancer Feature selection Risk prediction model Stability Evaluation of Feature Selection Techniques for Breast Cancer Risk Prediction