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oai:repisalud.isciii.es:20.500.12105/142752025-05-05T17:38:47Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19609

00925njm 22002777a 4500 dc Ceballos, Francisco C author Ryan, Pablo author Blancas, Rafael author Martin-Vicente, Maria author Vidal-Alcántara, Erick Joan author Perez-Garcia, Felipe author Bartolomé-Sánchez, Sofía author Churruca-Sarasqueta, Juan author Virseda-Berdices, Ana author Martínez-González, Oscar author Brochado-Kith, Oscar author Rava, Marta author Vilches-Medkouri, Carolina author Blanca-López, Natalia author Ramirez Martinez-Acitores, Ignacio author Moreira-Escriche, Patricia author De Juan, Carmen author Resino, Salvador author Fernandez-Rodriguez, Amanda author Jimenez-Sousa, Maria Angeles author 2021 Background: The link between coagulation system disorders and COVID-19 has not yet been fully elucidated. Aim: Evaluating the association of non-previously reported coagulation proteins with COVID-19 severity and mortality. Design: Cross-sectional study of 134 COVID-19 patients recruited at admission and classified according to the highest COVID-19 severity reached (asymptomatic/mild, moderate, or severe) and 16 healthy control individuals. Methods: Coagulation proteins levels (antithrombin, prothrombin, factor_XI, factor_XII, and factor_XIII) and CRP were measured in plasma by the ProcartaPlex Panel (Invitrogen) multiplex immunoassay upon diagnosis. Results: We found higher levels of antithrombin, prothrombin, factor XI, factor XII, and factor XIII in asymptomatic/mild and moderate COVID-19 patients compared to healthy individuals. Interestingly, decreased levels of antithrombin and factors XI, XII, and XIII were observed in those patients who eventually developed severe illness. Additionally, survival models showed us that patients with lower levels of these coagulation proteins had an increased risk of death. Conclusion: COVID-19 provokes early increments of some specific coagulation proteins in most patients. However, lower levels of these proteins at diagnosis might "paradoxically" imply a higher risk of progression to severe disease and COVID-19-related mortality. Front Med (Lausanne). 2021 Sep 30;8:718053. 10.3389/fmed.2021.718053 2296-858X Frontiers in Medicine 34660629 http://hdl.handle.net/20.500.12105/14275 COVID-19 SARS SARS-CoV-2 Coagulation factors Mortality Are Reduced Levels of Coagulation Proteins Upon Admission Linked to COVID-19 Severity and Mortality?