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00925njm 22002777a 4500 dc Papantoniou, Kyriaki author Castaño-Vinyals, Gemma author Espinosa, Ana author Turner, Michelle C author Martín-Sánchez, Vicente author Casabonne, Delphine author Aragones, Nuria author Gómez-Acebo, Inés author Ardanaz, Eva author Jimenez-Moleon, Jose J. author Amiano, Pilar author Molina-Barceló, Ana author Alguacil, Juan author Fernández-Tardón, Guillermo author Huerta, José María author Hernández-Segura, Natalia author Perez-Gomez, Beatriz author Llorca, Javier author Vidán-Alli, Juana author Olmedo-Requena, Rocío author Gil, Leire author Castañon-López, Carmen author Pollan-Santamaria, Marina author Kogevinas, Manolis author Moreno, Victor author 2021-06-03 Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case-control study (2008-2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR≥9 hours: 1.59; 95%CI 1.30-1.94) and gastric cancer (OR≥9 hours: 1.95; 1.37-2.76); short sleep was associated with increased odds of gastric cancer (OR≤5 hours: 1.32; 0.93-1.88). Frequent and long daytime naps increased the odds of colorectal (OR6-7 naps/week, ≥30 min: 1.32; 1.14-1.54) and gastric cancer (OR6-7 naps/week, ≥30 min: 1.56; 1.21-2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer. Sci Rep. 2021;11(1):11822. 10.1038/s41598-021-91275-3 2045-2322 Scientific Reports 34083698 http://hdl.handle.net/20.500.12105/14207 Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study