2026-04-29T07:23:38Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/141992025-04-07T18:42:25Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16961col_20.500.12105_16963col_20.500.12105_16978

00925njm 22002777a 4500 dc Donat-Vargas, Carolina author Guerrero-Zotano, Ángel author Casas, Ana María author Baena-Cañada, José Manuel author Lope Carvajal, Virginia author Antolín, Silvia author García-Sáenz, José Ángel author Bermejo, Begoña author Muñoz, Montserrat author Ramos, Manuel author de Juan, Ana author Jara Sánchez, Carlos author Sánchez-Rovira, Pedro author Antón, Antonio author Brunet, Joan author Gavilá, Joaquín author Salvador, Javier author Arriola-Arellano, Esperanza author Bezares, Susana author Fernandez de Larrea-Baz, Nerea author Perez-Gomez, Beatriz author Martín, Miguel author Pollan-Santamaria, Marina author 2021-09-06 Background: Wthere are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. Objective: To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). Methods: 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime. Results: Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (≥15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, ≥15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood. Conclusions: The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk. Br J Cancer. 2021 Oct;125(8):1168-1176. http://hdl.handle.net/20.500.12105/14199 34483338 10.1038/s41416-021-01492-w 1532-1827 British Journal of Cancer Alcohol consumption Breast cancer Risk factor Trajectories of alcohol consumption during life and the risk of developing breast cancer