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oai:repisalud.isciii.es:20.500.12105/141952024-11-28T17:16:17Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16959

00925njm 22002777a 4500 dc Rivera-Izquierdo, Mario author Pérez de Rojas, Javier author Martínez-Ruiz, Virginia author Perez-Gomez, Beatriz author Sánchez, María-José author Khan, Khalid Saeed author Jimenez-Moleon, Jose J. author 2021-08-19 The aim of this study was to systematically review all evidence evaluating obesity as a prognostic factor for PC mortality. Cohort and case-control studies reporting mortality among PC patients stratified by body mass index (BMI) were included. The risk of mortality among obese patients (BMI ≥ 30) was compared with the risk for normal weight (BMI < 25) patients, pooling individual hazard ratios (HR) in random-effects meta-analyses. Reasons for heterogeneity were assessed in subgroup analyses. Dose-response associations for BMI per 5 kg/m2 change were assessed. Among 7278 citations, 59 studies (280,199 patients) met inclusion criteria. Obesity was associated with increased PC-specific mortality (HR: 1.19, 95% CI: 1.10-1.28, I2: 44.4%) and all-cause mortality (HR: 1.09, 95% CI: 1.00-1.18, I2: 43.9%). There was a 9% increase (95% CI: 5-12%, I2: 39.4%) in PC-specific mortality and 3% increase (95% CI: 1-5%, I2: 24.3%) in all-cause mortality per 5 kg/m2 increase in BMI. In analyses restricted to the higher quality subgroup (NOS ≥ 8), obesity was associated with increased PC-specific mortality (HR: 1.24, 95% CI: 1.14-1.35, I2: 0.0%) and maintained the dose-response relationship (HR: 1.11 per 5 kg/m2 increase in BMI, 95% CI: 1.07-1.15, I2: 26.6%). Obesity had a moderate, consistent, temporal, and dose-response association with PC mortality. Weight control programs may have a role in improving PC survival. Cancers (Basel). 2021;13(16):4169. 10.3390/cancers13164169 2072-6694 Cancers 34439328 http://hdl.handle.net/20.500.12105/14195 All-cause mortality Body mass index Causation Outcomes Prostate cancer specific mortality Obesity as a Risk Factor for Prostate Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of 280,199 Patients