2026-06-14T03:37:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/141852025-05-13T00:15:20Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16974
Repisalud
author
González, Nerea
author
Loroño, Ane
author
Aguirre, Urko
author
Lázaro, Santiago
author
Baré, Marisa
author
Redondo, Maximino
author
Briones, Eduardo
author
Sarasqueta, Cristina
author
Bilbao, Amaia
author
Fernandez de Larrea-Baz, Nerea
author
Quintana, Jose Maria
author
REDISSEC-CARESS/CCR group
funder
Basque Government (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Kronikgune
2022-04-26T11:39:00Z
2022-04-26T11:39:00Z
2021-08-26
World J Surg Oncol. 2021;19(1):252.
10.1186/s12957-021-02356-6
1477-7819
World Journal of Surgical Oncology
34446044
http://hdl.handle.net/20.500.12105/14185
Background: The aim of this study was to identify predictors of mortality in elderly patients undergoing colorectal cancer surgery and to develop a risk score. Methods: This was an observational prospective cohort study. Individuals over 80 years diagnosed with colorectal cancer and treated surgically were recruited in 18 hospitals in the Spanish National Health Service, between June 2010 and December 2012, and were followed up 1, 2, 3, and 5 years after surgery. Sociodemographic and clinical data were collected. The primary outcomes were mortality at 2 and between 2 and 5 years after the index admission. Results: The predictors of mortality 2 years after surgery were haemoglobin ≤ 10 g/dl and colon locations (HR 1.02; CI 0.51-2.02), ASA class of IV (HR 3.55; CI 1.91-6.58), residual tumour classification of R2 (HR 7.82; CI 3.11-19.62), TNM stage of III (HR 2.14; CI 1.23-3.72) or IV (HR 3.21; CI 1.47-7), LODDS of more than - 0.53 (HR 3.08; CI 1.62-5.86)) and complications during admission (HR 1.73; CI 1.07-2.80). Between 2 and 5 years of follow-up, the predictors were no tests performed within the first year of follow-up (HR 2.58; CI 1.21-5.46), any complication due to the treatment within the 2 years of follow-up (HR 2.47; CI 1.27-4.81), being between 85 and 89 and not having radiotherapy within the second year of follow-up (HR 1.60; CI 1.01-2.55), no colostomy closure within the 2 years of follow-up (HR 4.93; CI 1.48-16.41), medical complications (HR 1.61; CI 1.06-2.44), tumour recurrence within the 2 years of follow-up period (HR 3.19; CI 1.96-5.18), and readmissions at 1 or 2 years of follow-up after surgery (HR 1.44; CI 0.86-2.41). Conclusion: We have identified variables that, in our sample, predict mortality 2 and between 2 and 5 years after surgery for colorectal cancer older patients. We have also created risks scores, which could support the decision-making process.
eng
Colorectal cancer
Elderly
Mortality
Outcome
Risk score
Surgery
Risk scores to predict mortality 2 and 5 years after surgery for colorectal cancer in elderly patients
research article
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RiskScoresToPredict_2021.pdf.txt
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