2026-05-21T23:54:24Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/141652024-11-28T16:14:06Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16938col_20.500.12105_16963col_20.500.12105_16970col_20.500.12105_16977col_20.500.12105_16978
Repisalud
author
Lozano-Ojalvo, Daniel
author
Camara, Carmen
author
Lopez-Granados, Eduardo
author
Nozal, Pilar
author
Del Pino-Molina, Lucía
author
Bravo-Gallego, Luz Yadira
author
Paz-Artal, Estela
author
Pion, Marjorie
author
Correa-Rocha, Rafael
author
Ortiz, Alberto
author
Lopez-Hoyos, Marcos
author
Iribarren, Marta Erro
author
Portoles, Jose
author
Rojo-Portoles, Maria Pilar
author
Ojeda, Gloria
author
Cervera Hernandez, Isabel
author
Gonzalez-Perez, Maria
author
Bodega-Mayor, Irene
author
Montes-Casado, Maria
author
Portoles, Pilar
author
Perez-Olmeda, Mayte
author
Oteo-Iglesias, Jesus
author
Sanchez-Tarjuelo, Rodrigo
author
Pothula, Venu
author
Schwarz, Megan
author
Brahmachary, Manisha
author
Tan, Anthony Tanoto
author
Le Bert, Nina
author
Berin, Cecilia
author
Bertoletti, Antonio
author
Guccione, Ernesto
author
Ochando, Jordi
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
NIH - National Cancer Institute (NCI) (Estados Unidos)
funder
Icahn School of Medicine at Mount Sinai
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Gobierno de Cantabria (España)
funder
Unión Europea. Comisión Europea. H2020
funder
National Institutes of Health (Estados Unidos)
2022-04-25T11:18:51Z
2022-04-25T11:18:51Z
2021-08-24
Cell Rep. 2021;36(8):109570.
10.1016/j.celrep.2021.109570
2211-1247
Cell Reports
34390647
http://hdl.handle.net/20.500.12105/14165
The rapid development of mRNA-based vaccines against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to the design of accelerated vaccination schedules that have been extremely effective in naive individuals. While a two-dose immunization regimen with the BNT162b2 vaccine has been demonstrated to provide a 95% efficacy in naive individuals, the effects of the second vaccine dose in individuals who have previously recovered from natural SARS-CoV-2 infection has not been investigated in detail. In this study, we characterize SARS-CoV-2 spike-specific humoral and cellular immunity in naive and previously infected individuals during and after two doses of BNT162b2 vaccination. Our results demonstrate that, while the second dose increases both the humoral and cellular immunity in naive individuals, COVID-19 recovered individuals reach their peak of immunity after the first dose. These results suggests that a second dose, according to the current standard regimen of vaccination, may be not necessary in individuals previously infected with SARS-CoV-2.
eng
BNT162b2 vaccine
COVID-19
SARS-CoV-2
T-cell immunity
Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals
research article
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File
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DifferentialEffectsOfThe_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/fa5146cc-6e0f-4120-afc9-c2a725e61796/download
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DifferentialEffectsOfThe_2021.pdf.txt