2026-06-14T03:37:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/141572025-06-26T09:56:28Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16964col_20.500.12105_16976
Repisalud
author
Delgado, Elena
author
Fernandez-Garcia, Aurora
author
Pérez-Losada, Marcos
author
Moreno-Lorenzo, María
author
Fernandez-Miranda, Ismael
author
Benito, Sonia
author
Montero, Vanessa
author
Gil, Horacio
author
Hernáez, Silvia
author
Muñoz, Josefa
author
Zubero-Sulibarria, Miren Z
author
Garcia-Bodas, Elena
author
Sanchez-Martinez, Monica
author
Del Romero, Jorge
author
Rodríguez, Carmen
author
Elorduy, Luis
author
Bereciartua, Elena
author
Culebras, Esther
author
Rodríguez-Avial, Icíar
author
Giménez-Alarcón, María Luisa
author
Martín-Salas, Carmen
author
Gómez-González, Carmen
author
García-Irure, José J
author
Cenzual, Gema
author
Martínez-Sapiña, Ana
author
Maiques-Camarero, María
author
Perez-Alvarez, Lucia
author
Thomson, Michael M
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Basque Government (España)
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
2022-04-22T14:56:37Z
2022-04-22T14:56:37Z
2021-06-01
Sci Rep. 2021 Jun 1;11(1):11442.
10.1038/s41598-021-90023-x
2045-2322
Scientific Reports
34075073
http://hdl.handle.net/20.500.12105/14157
Circulating recombinant forms (CRFs) contribute substantially to the HIV-1 pandemic. Among 105 CRFs described in the literature, 16 are BF intersubtype recombinants, most of South American origin, of which CRF12_BF is the most widely spread. A BF recombinant cluster identified in Bolivia was suggested to represent a new CRF_BF. Here we find that it belongs to a larger cluster incorporating 39 viruses collected in 7 countries from 3 continents, 22 of them in Spain, most from Bolivian or Peruvian individuals, and 12 in South America (Bolivia, Argentina, and Peru). This BF cluster comprises three major subclusters, two associated with Bolivian and one with Peruvian individuals. Near full-length genome sequence analyses of nine viruses, collected in Spain, Bolivia, and Peru, revealed coincident BF mosaic structures, with 13 breakpoints, 6 and 7 of which coincided with CRF12_BF and CRF17_BF, respectively. In a phylogenetic tree, they grouped in a clade closely related to these CRFs, and more distantly to CRF38_BF and CRF44_BF, all circulating in South America. These results allowed to identify a new HIV-1 CRF, designated CRF89_BF. Through phylodynamic analyses, CRF89_BF emergence was estimated in Bolivia around 1986. CRF89_BF is the fifth CRF member of the HIV-1 recombinant family related to CRF12_BF.
eng
Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America
research article
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
URL
https://repisalud.isciii.es/bitstreams/5e4d8a4a-29d9-498e-8a30-f315112c8132/download
File
MD5
e5bd228decf5fe7ff17ce0908a52ecc9
2137123
application/pdf
IdentificationOfCRF89BF_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/722d1bbd-399b-4ed3-93cc-414a9fbc2e83/download
File
MD5
0e2679da6d7c8d91575b0e61417d99a1
1374754
application/pdf
IdentificationOfCRF89BFSupplementaryInformation_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/14506af8-0dcc-46aa-93c9-caefa395fd32/download
File
MD5
9f320a1dee781b07f03a069837e20d07
742305
application/pdf
AuthorCorrectionIdentificationOf_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/eb613ddc-f66a-4988-b933-7ba23abaef12/download
File
MD5
0a954196923e8c666d3bef480a9735f9
58437
text/plain
IdentificationOfCRF89BF_2021.pdf.txt
URL
https://repisalud.isciii.es/bitstreams/b677805c-cc8d-4564-94b7-ff755336b752/download
File
MD5
fa1eef3333331f827ec4aef68ea45e0d
2738
text/plain
AuthorCorrectionIdentificationOf_2021.pdf.txt
URL
https://repisalud.isciii.es/bitstreams/1f62f16f-b289-4387-bd5b-5fb9dcefc370/download
File
MD5
c62de4b92cd00d395f71a2a8ef00d50b
11097
text/plain
IdentificationOfCRF89BFSupplementaryInformation_2021.pdf.txt