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00925njm 22002777a 4500 dc Delgado, Elena author Fernandez-Garcia, Aurora author Pérez-Losada, Marcos author Moreno-Lorenzo, María author Fernandez-Miranda, Ismael author Benito, Sonia author Montero, Vanessa author Gil, Horacio author Hernáez, Silvia author Muñoz, Josefa author Zubero-Sulibarria, Miren Z author Garcia-Bodas, Elena author Sanchez-Martinez, Monica author Del Romero, Jorge author Rodríguez, Carmen author Elorduy, Luis author Bereciartua, Elena author Culebras, Esther author Rodríguez-Avial, Icíar author Giménez-Alarcón, María Luisa author Martín-Salas, Carmen author Gómez-González, Carmen author García-Irure, José J author Cenzual, Gema author Martínez-Sapiña, Ana author Maiques-Camarero, María author Perez-Alvarez, Lucia author Thomson, Michael M author 2021-06-01 Circulating recombinant forms (CRFs) contribute substantially to the HIV-1 pandemic. Among 105 CRFs described in the literature, 16 are BF intersubtype recombinants, most of South American origin, of which CRF12_BF is the most widely spread. A BF recombinant cluster identified in Bolivia was suggested to represent a new CRF_BF. Here we find that it belongs to a larger cluster incorporating 39 viruses collected in 7 countries from 3 continents, 22 of them in Spain, most from Bolivian or Peruvian individuals, and 12 in South America (Bolivia, Argentina, and Peru). This BF cluster comprises three major subclusters, two associated with Bolivian and one with Peruvian individuals. Near full-length genome sequence analyses of nine viruses, collected in Spain, Bolivia, and Peru, revealed coincident BF mosaic structures, with 13 breakpoints, 6 and 7 of which coincided with CRF12_BF and CRF17_BF, respectively. In a phylogenetic tree, they grouped in a clade closely related to these CRFs, and more distantly to CRF38_BF and CRF44_BF, all circulating in South America. These results allowed to identify a new HIV-1 CRF, designated CRF89_BF. Through phylodynamic analyses, CRF89_BF emergence was estimated in Bolivia around 1986. CRF89_BF is the fifth CRF member of the HIV-1 recombinant family related to CRF12_BF. Sci Rep. 2021 Jun 1;11(1):11442. 10.1038/s41598-021-90023-x 2045-2322 Scientific Reports 34075073 http://hdl.handle.net/20.500.12105/14157 Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America