2026-06-14T03:39:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/141562025-06-09T11:05:13Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16988
Repisalud
author
Botana, Laura
author
Ibarra-Meneses, Ana Victoria
author
Sanchez Herrero, Carmen
author
Matia, Belen
author
San Martín, Juan Víctor
author
Moreno, Javier
author
Carrillo, Eugenia
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
RETICS-Investigación colaborativa en Enfermedades Tropicales (RICET-ISCIII) (España)
2022-04-22T14:26:08Z
2022-04-22T14:26:08Z
2021-08
PLoS Negl Trop Dis. 2021;15(8):e0009662.
10.1371/journal.pntd.0009662
1935-2735
PLoS Neglected Tropical Diseases
34339445
http://hdl.handle.net/20.500.12105/14156
Visceral leishmaniasis (VL) in patients receiving immunosuppressant drugs for autoimmune disease has been on the rise. It is important-but difficult-to know when cure has been achieved in these patients since the withdrawal of immunosuppressants during antileishmania treatment is commonly required, and there is a risk of relapse when immunosuppression is restored. The prevalence of asymptomatic infection among those immunosuppressed for autoimmune disease is also uncertain. The present work describes how cytokine release assays can be used to confirm the cure of VL, and to determine the prevalence of asymptomatic infection, in such patients. After collection of blood from volunteers (n = 108), SLA-stimulation of peripheral blood mononuclear cell cultures and of whole blood was found to induce the production of different combinations of cytokines that served to confirm recovery from VL, and asymptomatic Leishmania infection. Indeed, cure was confirmed in 14 patients, all of whom showed a specific Th1 immune response against Leishmania, and the prevalence of asymptomatic infection was determined as 21.27%. Cytokine profiles could be used to manage VL in patients with autoimmune disease, and to identify and better protect those with asymptomatic infection who are at risk of developing this disease.
eng
Leishmaniasis: A new method for confirming cure and detecting asymptomatic infection in patients receiving immunosuppressive treatment for autoimmune disease
research article
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URL
https://repisalud.isciii.es/bitstreams/17d92b23-cd66-48d6-8f6b-a5667fd8526d/download
File
MD5
7fcb06d2d927a24c8f23e60a31e5cb5b
1001494
application/pdf
LeishmaniasisANewMethod_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/8aad65fd-e513-4db0-9e5d-680425a38670/download
File
MD5
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text/plain
LeishmaniasisANewMethod_2021.pdf.txt