2026-06-14T03:40:04Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/141292025-04-29T11:06:53Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16973col_20.500.12105_19617
Repisalud
author
Belmar-López, Carolina
author
Vassaux, Georges
author
Medel-Martínez, Ana
author
Burnet, Jerome
author
Quintanilla, Miguel
author
Ramón y Cajal, Santiago
author
Hernandez-Losa, Javier
author
De la Vieja, Antonio
author
Martin-Duque, Pilar
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Gobierno de Aragón (España)
funder
Ministerio de Economía y Competitividad (España)
2022-04-20T09:55:48Z
2022-04-20T09:55:48Z
2022-01-31
Int J Mol Sci. 2022;23(3):1682.
10.3390/ijms23031682
1422-0067
International Journal of Molecular Sciences
35163605
http://hdl.handle.net/20.500.12105/14129
Due to their ease of isolation and their properties, mesenchymal stem cells (MSCs) have been widely investigated. MSCs have been proved capable of migration towards areas of inflammation, including tumors. Therefore, they have been suggested as vectors to carry therapies, specifically to neoplasias. As most of the individuals joining clinical trials that use MSCs for cancer and other pathologies are carefully recruited and do not suffer from other diseases, here we decided to study the safety and application of iv-injected MSCs in animals simultaneously induced with different inflammatory pathologies (diabetes, wound healing and tumors). We studied this by in vitro and in vivo approaches using different gene reporters (GFP, hNIS, and f-Luc) and non-invasive techniques (PET, BLI, or fluorescence). Our results found that MSCs reached different organs depending on the previously induced pathology. Moreover, we evaluated the property of MSCs to target tumors as vectors to deliver adenoviruses, including the interaction between tumor microenvironment and MSCs on their arrival. Mechanisms such as transdifferentiation, MSC fusion with cells, or paracrine processes after MSCs homing were studied, increasing the knowledge and safety of this new therapy for cancer.
eng
Imaging PET
SPECT
Bioluminescence
Diabetes
Injury
Luciferase
Mesenchymal stem cells
Radioiodine therapy
Sodium/iodide symporter (NIS)
Therapy
Transdifferentiation
Mesenchymal Stem Cells Delivery in Individuals with Different Pathologies: Multimodal Tracking, Safety and Future Applications
research article
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URL
https://repisalud.isciii.es/bitstreams/3c4aa5fe-5d0a-49fd-b754-3523af97c159/download
File
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application/pdf
MesenchymalStemCellsDelivery_2022.pdf
URL
https://repisalud.isciii.es/bitstreams/750ec368-4883-477e-9594-9dc941ef90a1/download
File
MD5
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text/plain
MesenchymalStemCellsDelivery_2022.pdf.txt