2026-05-17T05:52:33Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/141292025-04-29T11:06:53Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16973col_20.500.12105_19617

00925njm 22002777a 4500 dc Belmar-López, Carolina author Vassaux, Georges author Medel-Martínez, Ana author Burnet, Jerome author Quintanilla, Miguel author Ramón y Cajal, Santiago author Hernandez-Losa, Javier author De la Vieja, Antonio author Martin-Duque, Pilar author 2022-01-31 Due to their ease of isolation and their properties, mesenchymal stem cells (MSCs) have been widely investigated. MSCs have been proved capable of migration towards areas of inflammation, including tumors. Therefore, they have been suggested as vectors to carry therapies, specifically to neoplasias. As most of the individuals joining clinical trials that use MSCs for cancer and other pathologies are carefully recruited and do not suffer from other diseases, here we decided to study the safety and application of iv-injected MSCs in animals simultaneously induced with different inflammatory pathologies (diabetes, wound healing and tumors). We studied this by in vitro and in vivo approaches using different gene reporters (GFP, hNIS, and f-Luc) and non-invasive techniques (PET, BLI, or fluorescence). Our results found that MSCs reached different organs depending on the previously induced pathology. Moreover, we evaluated the property of MSCs to target tumors as vectors to deliver adenoviruses, including the interaction between tumor microenvironment and MSCs on their arrival. Mechanisms such as transdifferentiation, MSC fusion with cells, or paracrine processes after MSCs homing were studied, increasing the knowledge and safety of this new therapy for cancer. Int J Mol Sci. 2022;23(3):1682. 10.3390/ijms23031682 1422-0067 International Journal of Molecular Sciences 35163605 http://hdl.handle.net/20.500.12105/14129 Imaging PET SPECT Bioluminescence Diabetes Injury Luciferase Mesenchymal stem cells Radioiodine therapy Sodium/iodide symporter (NIS) Therapy Transdifferentiation Mesenchymal Stem Cells Delivery in Individuals with Different Pathologies: Multimodal Tracking, Safety and Future Applications