2026-06-14T03:31:03Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/141282025-05-07T09:05:29Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16958col_20.500.12105_16963col_20.500.12105_16970col_20.500.12105_16986col_20.500.12105_16988col_20.500.12105_16990col_20.500.12105_19617
Repisalud
author
de Rojas, Itziar
author
Hernández, Isabel
author
Montrreal, Laura
author
Quintela, Inés
author
Calero, Miguel
author
Royo, José Luis
author
Huerto Vilas, Raquel
author
González-Pérez, Antonio
author
Franco-Macías, Emilio
author
Macías, Juan
author
Menéndez-González, Manuel
author
Frank-García, Ana
author
Diez-Fairen, Mónica
author
Lage, Carmen
author
García-Madrona, Sebastián
author
Aguilera, Nuria
author
García-González, Pablo
author
Puerta, Raquel
author
Sotolongo-Grau, Oscar
author
Alonso-Lana, Silvia
author
Rábano, Alberto
author
Arias Pastor, Alfonso
author
Pastor, Ana Belén
author
Corma-Gómez, Anaïs
author
Martín Montes, Angel
author
Martínez Rodríguez, Carmen
author
Buiza-Rueda, Dolores
author
Periñán, Maria Teresa
author
Rodriguez-Rodriguez, Eloy
author
Alvarez, Ignacio
author
Rosas Allende, Irene
author
Pineda, Juan A
author
Bernal Sánchez-Arjona, María
author
Fernández-Fuertes, Marta
author
Mendoza, Silvia
author
Del Ser, Teodoro
author
GR@ACE/DEGESCO Consortium
author
Garcia-Ribas, Guillermo
author
Sánchez-Juan, Pascual
author
Pastor, Pau
author
Bullido, María Jesús
author
Álvarez, Victoria
author
Real, Luis M
author
Mir, Pablo
author
Piñol-Ripoll, Gerard
author
García-Alberca, Jose María
author
Medina, Miguel
author
Orellana, Adelina
author
Butler, Chris R
author
Marquié, Marta
author
Sáez, María Eugenia
author
Carracedo, Ángel
author
Tárraga, Lluís
author
Boada, Mercè
author
Ruiz, Agustín
funder
Instituto de Salud Carlos III
funder
Unión Europea
funder
Grifols (Spain)
funder
Fundación La Caixa
funder
Fundació ACE
funder
Centro de Investigación Biomédica en Red - CIBERNED (Enfermedades Neurodegenerativas)
funder
Fundación Reina Sofía
2022-04-20T09:48:19Z
2022-04-20T09:48:19Z
2021-12-07
J Pers Med. 2021 Dec 7;11(12):1318.
10.3390/jpm11121318
2075-4426
Journal of Personalized Medicine
34945790
http://hdl.handle.net/20.500.12105/14128
Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.
eng
APOE
COVID-19
GR@ACE/DEGESCO
GWAS
SARS-CoV-2
dementia
Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study
research article
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
URL
https://repisalud.isciii.es/bitstreams/c86c8527-2b49-4f37-87f5-6c3b1e130096/download
File
MD5
7db8f7ad53af496d01e1c1477c9a9052
614087
application/pdf
GenomicCharacterizationHostFactors_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/50eb17e1-ac9b-415c-9b13-de159dc99b48/download
File
MD5
6c6298c498211cecab3c72f6e238bfa9
18530
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
GenomicCharacterizationHostFactorssupplementaryTableS1_2021.xlsx
URL
https://repisalud.isciii.es/bitstreams/6a91a8df-1376-4c45-b80c-2f561c1e66cb/download
File
MD5
1bd182acb3e2ebcd0f9fc77977cde5b5
16491
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
GenomicCharacterizationHostFactorssupplementaryTableS2_2021.xlsx
URL
https://repisalud.isciii.es/bitstreams/a20d3d9d-b079-4b3b-8472-6c147aea195e/download
File
MD5
51922e1e16e09e903517a0b64974bd96
17180
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
GenomicCharacterizationHostFactorssupplementaryTableS3_2021.xlsx
URL
https://repisalud.isciii.es/bitstreams/9beb11c0-06e5-4d84-8383-e81d29ef788f/download
File
MD5
c025fd7b6a86badf3ebc545f39fc964a
45852
text/plain
GenomicCharacterizationHostFactors_2021.pdf.txt
URL
https://repisalud.isciii.es/bitstreams/de743721-f4d4-4eec-b1a6-33a13bf7784a/download
File
MD5
51a9d1840962f18a31fd4c093893d1a9
7564
text/plain
GenomicCharacterizationHostFactorssupplementaryTableS1_2021.xlsx.txt
URL
https://repisalud.isciii.es/bitstreams/6072a6d8-b697-42af-935b-e13a99878763/download
File
MD5
672ff5ac02a71b9f0214b262b8311d1e
6421
text/plain
GenomicCharacterizationHostFactorssupplementaryTableS2_2021.xlsx.txt
URL
https://repisalud.isciii.es/bitstreams/e37338a6-6f50-41d2-87c6-be0be6577d75/download
File
MD5
613f7745ba5e95d3faee5d2c00d33949
5136
text/plain
GenomicCharacterizationHostFactorssupplementaryTableS3_2021.xlsx.txt