2026-06-14T03:33:49Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/141282025-05-07T09:05:29Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16958col_20.500.12105_16963col_20.500.12105_16970col_20.500.12105_16986col_20.500.12105_16988col_20.500.12105_16990col_20.500.12105_19617

00925njm 22002777a 4500 dc de Rojas, Itziar author Hernández, Isabel author Montrreal, Laura author Quintela, Inés author Calero, Miguel author Royo, José Luis author Huerto Vilas, Raquel author González-Pérez, Antonio author Franco-Macías, Emilio author Macías, Juan author Menéndez-González, Manuel author Frank-García, Ana author Diez-Fairen, Mónica author Lage, Carmen author García-Madrona, Sebastián author Aguilera, Nuria author García-González, Pablo author Puerta, Raquel author Sotolongo-Grau, Oscar author Alonso-Lana, Silvia author Rábano, Alberto author Arias Pastor, Alfonso author Pastor, Ana Belén author Corma-Gómez, Anaïs author Martín Montes, Angel author Martínez Rodríguez, Carmen author Buiza-Rueda, Dolores author Periñán, Maria Teresa author Rodriguez-Rodriguez, Eloy author Alvarez, Ignacio author Rosas Allende, Irene author Pineda, Juan A author Bernal Sánchez-Arjona, María author Fernández-Fuertes, Marta author Mendoza, Silvia author Del Ser, Teodoro author GR@ACE/DEGESCO Consortium author Garcia-Ribas, Guillermo author Sánchez-Juan, Pascual author Pastor, Pau author Bullido, María Jesús author Álvarez, Victoria author Real, Luis M author Mir, Pablo author Piñol-Ripoll, Gerard author García-Alberca, Jose María author Medina, Miguel author Orellana, Adelina author Butler, Chris R author Marquié, Marta author Sáez, María Eugenia author Carracedo, Ángel author Tárraga, Lluís author Boada, Mercè author Ruiz, Agustín author 2021-12-07 Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis. J Pers Med. 2021 Dec 7;11(12):1318. 10.3390/jpm11121318 2075-4426 Journal of Personalized Medicine 34945790 http://hdl.handle.net/20.500.12105/14128 APOE COVID-19 GR@ACE/DEGESCO GWAS SARS-CoV-2 dementia Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study