2026-06-14T03:45:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/141262025-05-16T10:17:34Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616
Repisalud
author
Llamosas-Falcón, Laura
author
Sanchez-Diaz, German
author
Gallego, Elisa
author
Villaverde-Hueso, Ana
author
Arias-Merino, Greta
author
Posada De la Paz, Manuel
author
Alonso-Ferreira, Veronica
funder
Instituto de Salud Carlos III
2022-04-20T09:28:46Z
2022-04-20T09:28:46Z
2022-03-08
Sci Rep. 2022;12(1):3750.
10.1038/s41598-022-07814-z
2045-2322
Scientific Reports
35260676
http://hdl.handle.net/20.500.12105/14126
Muscular dystrophies (MD) are a group of rare hereditary degenerative diseases. Our aim was to analyze the mortality pattern in Spain from 1981 to 2016 to assess the temporal trend and discern possible geographic differences using population-based data. Annual deaths related to MD were obtained from the National Statistics Institute with codes 359.1 of the ICD-9 (1981-1998) and G71.0 of the ICD-10 (1999-2016). Age-adjusted mortality rates were calculated and changes in mortality trends were identified. The standardized mortality ratios (SMR) and their respective 95% confidence intervals were calculated by district for 1999-2016. Smoothed SMRs and posterior probability were also assessed and then mapped to look for patterns or geographic distribution. All rates were expressed per 1,000,000 inhabitants. A total of 2,512 deaths (73.8% men) were identified. The age-adjusted mortality rates varied from 0.63 (95% CI 0.40-0.95) in 1981 to 1.51 (95% CI 1.17-1.93) in 2016. MD mortality showed a significant increase of 8.81% per year (95% CI 5.0-12.7) from 1981 to 1990, remaining stable afterwards. Areas with risk of death higher than expected for Spain as a whole were identified, not showing a specific regional pattern. In conclusion, the rising trend in MD mortality might be attributable to advanced improvements in diagnostic techniques leading to a rise in prevalence. Further research on the districts with the highest mortality would be necessary.
eng
A population-based study of mortality due to muscular dystrophies across a 36-year period in Spain
research article
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URL
https://repisalud.isciii.es/bitstreams/d2754acd-3c5a-42c7-a444-cc9239a6a83a/download
File
MD5
de3b3ed7b95eb730c65c9e9db978d00d
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application/pdf
PopulationBasedStudyMortality_2022.pdf
URL
https://repisalud.isciii.es/bitstreams/f20ac8e5-43a9-474e-9bf7-2a69781d0d9f/download
File
MD5
e4e5db55881fd72e66bf86be401b65aa
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text/plain
PopulationBasedStudyMortality_2022.pdf.txt