2026-06-14T03:45:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/139812025-05-07T10:07:15Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16978
Repisalud
author
Rodríguez-Izquierdo, Ignacio
author
Ceña-Diez, Rafael
author
Serramia, Maria Jesús
author
Rodríguez-Fernández, Rosa
author
Martinez, Isidoro
author
Muñoz-Fernández, María Ángeles
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Centro de Investigación Biomédica en Red - CIBERBBN (Bioingeniería, Biomateriales y Nanomedicina)
funder
Unión Europea. European Cooperation in Science and Technology (COST)
funder
Polish National Agency for Academic Exchange
2022-04-18T07:13:05Z
2022-04-18T07:13:05Z
2021-06-29
Polymers (Basel). 2021;13(13):2141.
10.3390/polym13132141
2073-4360
Polymers
34209827
http://hdl.handle.net/20.500.12105/13981
The respiratory syncytial virus (RSV) causes respiratory infection and bronchiolitis, requiring hospitalization mainly in infants. The interaction between RSV, envelope glycoproteins G and F, and cell surface heparan sulfate proteoglycans (HSPG) is required for binding and entry into the host cells. A G2-S16 polyanionic carbosilane dendrimer was identified as a possible RSV inhibitor. We speculated that the G2-S16 dendrimer adheres to the host cell-surface HSPG, acts through binding to HS receptors, and prevents further RSV infection. The G2-S16 dendrimer was non-toxic when applied intranasally to Balb/c mice, and interestingly enough, this G2-S16 dendrimer inhibits 85% RSV. Therefore, our G2-S16 dendrimer could be a candidate for developing a new possible therapy against RSV infection.
eng
G2-S16 dendrimer
RSV infection
Nanotechnology
Syncytium
Role of G2-S16 Polyanionic Carbosilane Dendrimer in the Prevention of Respiratory Syncytial Virus Infection In Vitro and In Vivo in Mice
research article
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URL
https://repisalud.isciii.es/bitstreams/016b6a2a-2ec4-4a7a-bf72-c8c4576e6b42/download
File
MD5
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2606561
application/pdf
RoleOfG2S16_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/40ccad3e-0958-483c-99df-868e7028ac08/download
File
MD5
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text/plain
RoleOfG2S16_2021.pdf.txt