2026-07-22T01:50:09Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/139812025-05-07T10:07:15Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16978

00925njm 22002777a 4500 dc Rodríguez-Izquierdo, Ignacio author Ceña-Diez, Rafael author Serramia, Maria Jesús author Rodríguez-Fernández, Rosa author Martinez, Isidoro author Muñoz-Fernández, María Ángeles author 2021-06-29 The respiratory syncytial virus (RSV) causes respiratory infection and bronchiolitis, requiring hospitalization mainly in infants. The interaction between RSV, envelope glycoproteins G and F, and cell surface heparan sulfate proteoglycans (HSPG) is required for binding and entry into the host cells. A G2-S16 polyanionic carbosilane dendrimer was identified as a possible RSV inhibitor. We speculated that the G2-S16 dendrimer adheres to the host cell-surface HSPG, acts through binding to HS receptors, and prevents further RSV infection. The G2-S16 dendrimer was non-toxic when applied intranasally to Balb/c mice, and interestingly enough, this G2-S16 dendrimer inhibits 85% RSV. Therefore, our G2-S16 dendrimer could be a candidate for developing a new possible therapy against RSV infection. Polymers (Basel). 2021;13(13):2141. 10.3390/polym13132141 2073-4360 Polymers 34209827 http://hdl.handle.net/20.500.12105/13981 G2-S16 dendrimer RSV infection Nanotechnology Syncytium Role of G2-S16 Polyanionic Carbosilane Dendrimer in the Prevention of Respiratory Syncytial Virus Infection In Vitro and In Vivo in Mice