2026-05-20T19:10:30Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/139682025-05-07T09:02:36Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16963

00925njm 22002777a 4500 dc Del Rosal, Teresa author Méndez-Echevarría, Ana author Garcia-Vera, Cesar author Escosa-Garcia, Luis author Agud, Martin author Chaves, Fernando author Roman, Federico author Gutiérrez-Fernández, José author Ruiz de Gopegui, Enrique author Ruiz-Carrascoso, Guillermo author Ruiz-Gallego, María del Carmen author Bernet, Albert author Quevedo, Sara Maria author Fernández-Verdugo, Ana Maria author Díez-Sebastian, Jesús author Calvo, Cristina author COSACO Study Group author 2020-12 Objective: To assess the prevalence and risk factors for S. aureus and methicillin-resistant S. aureus (MRSA) nasal colonization in Spanish children. Methods: Cross-sectional study of patients <14 years from primary care centers all over Spain. Clinical data and nasal aspirates were collected from March to July 2018. Results: A total of 1876 patients were enrolled. Prevalence of S. aureus and MRSA colonization were 33% (95% CI 30.9-35.1) and 1.44% (95% CI 0.9-2), respectively. Thirty-three percent of the children (633/1876) presented chronic conditions, mainly atopic dermatitis, asthma and/or allergy (524/633). Factors associated with S. aureus colonization were age ≥5 years (OR 1.10, 95% CI 1.07-1.12), male sex (OR 1.43, 95% CI 1.17-1.76), urban setting (OR 1.46, 95% CI 1.08-1.97) and the presence of asthma, atopic dermatitis or allergies (OR 1.25; 95% CI: 1.093-1.43). Rural residence was the only factor associated with MRSA colonization (OR 3.62, 95% CI 1.57-8.36). MRSA was more frequently resistant than methicillin-susceptible S. aureus to ciprofloxacin [41.2% vs 2.6%; p<0.0001], clindamycin [26% vs 16.9%; p=0.39], and mupirocin [14.3% vs 6.7%; p=0.18]. None of the MRSA strains was resistant to tetracycline, fosfomycin, vancomycin or daptomycin. Conclusions: The main risk factors for S. aureus colonization in Spanish children are being above five years of age, male gender, atopic dermatitis, asthma or allergy, and residence in urban areas. MRSA colonization is low, but higher than in other European countries and is associated with rural settings. Infect Drug Resist. 2020 Dec 23;13:4643-4651. 10.2147/IDR.S282880 1178-6973 Infection and Drug Resistance 33380814 http://hdl.handle.net/20.500.12105/13968 MRSA S. aureus Child Colonization Staphylococcus aureus Nasal Colonization in Spanish Children. The COSACO Nationwide Surveillance Study