2026-05-22T00:33:28Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/139592024-10-31T11:40:38Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Mair, Wesley
author
Lopez-Ruiz, Francisco
author
Stammler, Gerd
author
Clark, William
author
Burnett, Fiona
author
Hollomon, Derek
author
Ishii, Hideo
author
Thind, Tarlochan S
author
Brown, James Km
author
Fraaije, Bart
author
Cools, Hans
author
Shaw, Michael
author
Fillinger, Sabine
author
Walker, Anne-Sophie
author
Mellado, Emilia
author
Schnabel, Guido
author
Mehl, Andreas
author
Oliver, Richard P
2022-04-07T19:32:01Z
2022-04-07T19:32:01Z
2016-08
Pest Manag Sci. 2016 ;72(8):1449-59.
10.1002/ps.4301
1526-4998
Pest Management Science
27148866
http://hdl.handle.net/20.500.12105/13959
Evolved resistance to fungicides is a major problem limiting our ability to control agricultural, medical and veterinary pathogens and is frequently associated with substitutions in the amino acid sequence of the target protein. The convention for describing amino acid substitutions is to cite the wild-type amino acid, the codon number and the new amino acid, using the one-letter amino acid code. It has frequently been observed that orthologous amino acid mutations have been selected in different species by fungicides from the same mode of action class, but the amino acids have different numbers. These differences in numbering arise from the different lengths of the proteins in each species. The purpose of the present paper is to propose a system for unifying the labelling of amino acids in fungicide target proteins. To do this we have produced alignments between fungicide target proteins of relevant species fitted to a well-studied 'archetype' species. Orthologous amino acids in all species are then assigned numerical 'labels' based on the position of the amino acid in the archetype protein.
eng
Cyp51
SDHI
Fungicide
Mutation
Target site
Proposal for a unified nomenclature for target-site mutations associated with resistance to fungicides
journal article
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ProposalForAUnified_2016.pdf.txt
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ProposalForAUnifiedAppendixS1_2016.docx.txt