2026-06-14T10:38:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/139512025-04-01T12:26:51Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Oikonomou, Panteleimon
author
van Wamelen, Daniel J
author
Weintraub, Daniel
author
Aarsland, Dag
author
Ffytche, Dominic
author
Martínez-Martín, Pablo
author
Rodriguez-Blazquez, Carmen
author
Leta, Valentina
author
Borley, Corinne
author
Sportelli, Carolina
author
Trivedi, Dhaval
author
Podlewska, Aleksandra M
author
Rukavina, Katarina
author
Rizos, Alexandra
author
Lazcano-Ocampo, Claudia
author
Chaudhuri, Kallol Ray
funder
University of Freiburg (Alemania)
2022-04-07T10:29:13Z
2022-04-07T10:29:13Z
2021-05
Brain Behav. 2021;11(5):e02086.
10.1002/brb3.2086
2162-3279
Brain and Behavior
33645912
http://hdl.handle.net/20.500.12105/13951
Background: Identifying predictors of incident cognitive impairment (CI), one of the most problematic long-term outcomes, in Parkinson's disease (PD) is highly relevant for personalized medicine and prognostic counseling. The Nonmotor Symptoms Scale (NMSS) provides a global clinical assessment of a range of NMS, reflecting NMS burden (NMSB), and thus may assist in the identification of an "at-risk" CI group based on overall NMSB cutoff scores. Methods: To investigate whether specific patterns of PD NMS profiles predict incident CI, we performed a retrospective longitudinal study on a convenience sample of 541 nondemented PD patients taking part in the Nonmotor Longitudinal International Study (NILS) cohort, with Mini-Mental State Examination (MMSE), NMSS, and Scales for Outcomes in PD Motor Scale (SCOPA Motor) scores at baseline and last follow-up (mean 3.2 years) being available. Results: PD patients with incident CI (i.e., MMSE score ≤ 25) at last follow-up (n = 107) had severe overall NMSB level, significantly worse NMSS hallucinations/perceptual problems and higher NMSS attention/memory scores at baseline. Patients with CI also were older and with more advanced disease, but with no differences in disease duration, dopamine replacement therapy, sex, and comorbid depression, anxiety, and sleep disorders. Conclusions: Our findings suggest that a comprehensive baseline measure of NMS and in particular hallucinations and perceptual problems assessed with a validated single instrument can be used to predict incident CI in PD. This approach provides a simple, holistic strategy to predict future CI in this population.
eng
MMSE
Nonmotor symptom burden grading
Nonmotor symptoms
Parkinson's disease
Cognitive impairment
Nonmotor symptom burden grading as predictor of cognitive impairment in Parkinson's disease
research article
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NonmotorSymptomBurdenGrading_2021.pdf
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https://repisalud.isciii.es/bitstreams/f049ad48-ad1e-495f-90a0-55f209ff431d/download
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text/plain
NonmotorSymptomBurdenGrading_2021.pdf.txt