2026-06-14T10:39:20Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/139512025-04-01T12:26:51Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608

00925njm 22002777a 4500 dc Oikonomou, Panteleimon author van Wamelen, Daniel J author Weintraub, Daniel author Aarsland, Dag author Ffytche, Dominic author Martínez-Martín, Pablo author Rodriguez-Blazquez, Carmen author Leta, Valentina author Borley, Corinne author Sportelli, Carolina author Trivedi, Dhaval author Podlewska, Aleksandra M author Rukavina, Katarina author Rizos, Alexandra author Lazcano-Ocampo, Claudia author Chaudhuri, Kallol Ray author 2021-05 Background: Identifying predictors of incident cognitive impairment (CI), one of the most problematic long-term outcomes, in Parkinson's disease (PD) is highly relevant for personalized medicine and prognostic counseling. The Nonmotor Symptoms Scale (NMSS) provides a global clinical assessment of a range of NMS, reflecting NMS burden (NMSB), and thus may assist in the identification of an "at-risk" CI group based on overall NMSB cutoff scores. Methods: To investigate whether specific patterns of PD NMS profiles predict incident CI, we performed a retrospective longitudinal study on a convenience sample of 541 nondemented PD patients taking part in the Nonmotor Longitudinal International Study (NILS) cohort, with Mini-Mental State Examination (MMSE), NMSS, and Scales for Outcomes in PD Motor Scale (SCOPA Motor) scores at baseline and last follow-up (mean 3.2 years) being available. Results: PD patients with incident CI (i.e., MMSE score ≤ 25) at last follow-up (n = 107) had severe overall NMSB level, significantly worse NMSS hallucinations/perceptual problems and higher NMSS attention/memory scores at baseline. Patients with CI also were older and with more advanced disease, but with no differences in disease duration, dopamine replacement therapy, sex, and comorbid depression, anxiety, and sleep disorders. Conclusions: Our findings suggest that a comprehensive baseline measure of NMS and in particular hallucinations and perceptual problems assessed with a validated single instrument can be used to predict incident CI in PD. This approach provides a simple, holistic strategy to predict future CI in this population. Brain Behav. 2021;11(5):e02086. 10.1002/brb3.2086 2162-3279 Brain and Behavior 33645912 http://hdl.handle.net/20.500.12105/13951 MMSE Nonmotor symptom burden grading Nonmotor symptoms Parkinson's disease Cognitive impairment Nonmotor symptom burden grading as predictor of cognitive impairment in Parkinson's disease