2026-08-29T10:10:15Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/138972025-05-12T10:49:34Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610
Repisalud author Santonen, Tiina author Alimonti, Alessandro author Bocca, Beatrice author Duca, Radu Corneliu author Galea, Karen S author Godderis, Lode author Göen, Thomas author Gomes, Bruno author Hanser, Ogier author Iavicoli, Ivo author Janasik, Beata author Jones, Kate author Kiilunen, Mirja author Koch, Holger M author Leese, Elizabeth author Leso, Veruscka author Louro, Henriqueta author Ndaw, Sophie author Porras, Simo P author Robert, Alain author Ruggieri, Flavia author Scheepers, Paul T J author Silva, Maria J author Viegas, Susana author Wasowicz, Wojciech author Castaño, Argelia author Sepai, Ovnair funder Unión Europea. Comisión Europea. H2020 2022-03-30T06:36:46Z 2022-03-30T06:36:46Z 2019-10 Environ Res. 2019 Oct;177:108583. 10.1016/j.envres.2019.108583 1096-0953 Environmental Research 31330491 http://hdl.handle.net/20.500.12105/13897 The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure to relevant priority chemicals and developing new approaches for occupational biomonitoring. In this manuscript, the hexavalent chromium [Cr(VI)] study design is presented as the first example of this HBM4EU approach. This study involves eight European countries and plans to recruit 400 workers performing Cr(VI) surface treatment e.g. electroplating or stainless steel welding activities. The aim is to collect new data on current occupational exposure to Cr(VI) in Europe and to test new methods for Cr biomonitoring, specifically the analysis of Cr(VI) in exhaled breath condensate (EBC) and Cr in red blood cells (RBC) in addition to traditional urinary total Cr analyses. Furthermore, exposure data will be complemented with early biological effects data, including genetic and epigenetic effects. Personal air samples and wipe samples are collected in parallel to help informing the biomonitoring results. We present standard operational procedures (SOPs) to support the harmonized methodologies for the collection of occupational hygiene and HBM samples in different countries. eng Biomonitoring Effect markers Electroplating Exhaled breath condensate Hexavalent chromium Multicenter study Occupational exposure Welding Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium research article TElDRU5DSUEgREUgRElTVFJJQlVDScOTTiBOTyBFWENMVVNJVkEKCkFjZXB0YW5kbyBlc3RhIGxpY2VuY2lhLCBVc3RlZCAoZWwgYXV0b3IvZXMgbyBlbCBwcm9waWV0YXJpby9zIGRlIGxvcyBkZXJlY2hvcyBkZSAKYXV0b3IpIGNvbmNlZGUgYSBSRVBJU0FMVUQgZWwgZGVyZWNobyBubyBleGNsdXNpdm8gZGUgcmVwcm9kdWNpciwgY29udmVydGlyLCB5L28gCmRpc3RyaWJ1aXIgc3UgZG9jdW1lbnRvIChpbmNsdXllbmRvIHN1IHJlc3VtZW4pIGEgbml2ZWwgbXVuZGlhbCBlbiBmb3JtYXRvIGRpZ2l0YWwsIAppbmNsdXllbmRvLCBhdWRpbyB5IHbDrWRlbywgYSB0cmF2w6lzIGRlIHN1IHJlcG9zaXRvcmlvIGluc3RpdHVjaW9uYWwuCgpVc3RlZCBhY2VwdGEgcXVlIFJFUElTQUxVRCBwdWVkZSwgc2luIGFsdGVyYXIgc3UgY29udGVuaWRvLCBjb252ZXJ0aXIgc3UgZG9jdW1lbnRvIAphIGN1YWxxdWllciBvdHJvIGZvcm1hdG8gZGlnaXRhbCBkZSBkYXRvcywgYXVkaW8geSB2aWRlbywgY29uIGVsIHByb3DDs3NpdG8gZGUgcXVlIApwdWVkYSBzZXIgYWxvamFkbyBlbiBlbCByZXBvc2l0b3Jpby4gCgpVc3RlZCBlc3TDoSBkZSBhY3VlcmRvIGNvbiBxdWUgUkVQSVNBTFVEIHB1ZWRhIGNvbnNlcnZhciBtw6FzIGRlIHVuYSBjb3BpYSBkZSBlc3RlIApkb2N1bWVudG8gcGFyYSBhc2VndXJhciBzdSBzZWd1cmlkYWQsIHByZXNlcnZhY2nDs24geSBhY2Nlc28uCgpVc3RlZCBkZWNsYXJhIHF1ZSBlbCBkb2N1bWVudG8gZXMgdW4gdHJhYmFqbyBvcmlnaW5hbCwgeSBxdWUgdGllbmUgZWwgZGVyZWNobyBkZSAKb3RvcmdhciBsb3MgZGVyZWNob3MgY29udGVuaWRvcyBlbiBlc3RhIGxpY2VuY2lhLiBUYW1iacOpbiBkZWNsYXJhIHF1ZSBzdSBwZXRpY2nDs24gCm5vIGluZnJpbmdlIGxvcyBkZXJlY2hvcyBkZSBhdXRvciBkZSBuYWRpZS4gCgpTaSBlbCBkb2N1bWVudG8gY29udGllbmUgbWF0ZXJpYWxlcyBwYXJhIGxvcyBxdWUgbm8gc2UgdGllbmVuIGxvcyBkZXJlY2hvcyBkZSBhdXRvciwgClVzdGVkIGRlY2xhcmEgcXVlIGhhIG9idGVuaWRvIGVsIHBlcm1pc28gc2luIHJlc3RyaWNjacOzbiBkZWwgcHJvcGlldGFyaW8gZGUgbG9zIApkZXJlY2hvcyB5IHF1ZSBlbiBkaWNobyBtYXRlcmlhbCwgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZGEgeSByZWNvbm9jaWRhIHN1IAphdXRvcsOtYSBkZW50cm8gZWwgdGV4dG8gbyBkZWwgY29udGVuaWRvIGRlIGRpY2hvIGRvY3VtZW50by4gCgpTaSBlbCBlbnbDrW8gc2UgYmFzYSBlbiB1biB0cmFiYWpvIHF1ZSBoYSBzaWRvIHBhdHJvY2luYWRvIG8gYXBveWFkbyBwb3IgdW5hIGFnZW5jaWEgCnUgb3JnYW5pemFjacOzbiBkaXN0aW50YSBhIFJFUElTQUxVRCwgdXN0ZWQgYWNlcHRhIHF1ZSBoYSBjdW1wbGlkbyBjb24gZWwgZGVyZWNobyBkZSAKcmV2aXNpw7NuIHkgb3RyYXMgb2JsaWdhY2lvbmVzIHJlcXVlcmlkYXMgcG9yIGNvbnRyYXRvIG8gYWN1ZXJkby4gCgpSRVBJU0FMVUQgaWRlbnRpZmljYXLDoSBjbGFyYW1lbnRlIHN1KHMpIG5vbWJyZShzKSBjb21vIGF1dG9yKHMpIG8gcHJvcGlldGFyaW8ocykgCmRlbCBkb2N1bWVudG8sIHkgbm8gaGFyw6EgbmluZ3VuYSBhbHRlcmFjacOzbiwgZXhjZXB0byBzZWfDum4gbG8gcGVybWl0aWRvIHBvciBlc3RhIApsaWNlbmNpYS4gCg== URL https://repisalud.isciii.es/bitstreams/4ce11bb7-0c4e-4e5f-b68b-cc25ac138515/download File MD5 ee0dd2dfef4e5d892b7b77ad597d74aa 899817 application/pdf SettingUpACollaborative_2019.pdf URL https://repisalud.isciii.es/bitstreams/22202759-57fb-4e64-a725-36338a3f3f56/download File MD5 3ba44733cdc058a77585c6b05f324bf5 5176132 application/pdf SettingUpACollaborativeSupplementaryDatammc1_2019.pdf URL https://repisalud.isciii.es/bitstreams/07721e31-f8dc-4560-aa63-1daaa2c3d4ca/download File MD5 1d6cac06d0c642a7dd56a8fff7452ea8 678590 application/pdf SettingUpACollaborativeSupplementaryDatammc2_2019.pdf URL https://repisalud.isciii.es/bitstreams/87bbe0c0-3f7e-47bd-b0d3-cb71a71f678f/download File MD5 188ce127f4ff81648ec8e6d1f8418c29 75646 text/plain SettingUpACollaborative_2019.pdf.txt URL https://repisalud.isciii.es/bitstreams/1da8595f-dff8-49fb-9a5f-f3d1f46832ba/download File MD5 29f8645b483d35273d97706e839fb3b7 192962 text/plain SettingUpACollaborativeSupplementaryDatammc1_2019.pdf.txt URL https://repisalud.isciii.es/bitstreams/7a32b516-c23d-4836-90df-344174954cf9/download File MD5 b83730910e42ad5b2766de8e088e9754 21717 text/plain SettingUpACollaborativeSupplementaryDatammc2_2019.pdf.txt