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oai:repisalud.isciii.es:20.500.12105/138972025-05-12T10:49:34Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610

00925njm 22002777a 4500 dc Santonen, Tiina author Alimonti, Alessandro author Bocca, Beatrice author Duca, Radu Corneliu author Galea, Karen S author Godderis, Lode author Göen, Thomas author Gomes, Bruno author Hanser, Ogier author Iavicoli, Ivo author Janasik, Beata author Jones, Kate author Kiilunen, Mirja author Koch, Holger M author Leese, Elizabeth author Leso, Veruscka author Louro, Henriqueta author Ndaw, Sophie author Porras, Simo P author Robert, Alain author Ruggieri, Flavia author Scheepers, Paul T J author Silva, Maria J author Viegas, Susana author Wasowicz, Wojciech author Castaño, Argelia author Sepai, Ovnair author 2019-10 The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure to relevant priority chemicals and developing new approaches for occupational biomonitoring. In this manuscript, the hexavalent chromium [Cr(VI)] study design is presented as the first example of this HBM4EU approach. This study involves eight European countries and plans to recruit 400 workers performing Cr(VI) surface treatment e.g. electroplating or stainless steel welding activities. The aim is to collect new data on current occupational exposure to Cr(VI) in Europe and to test new methods for Cr biomonitoring, specifically the analysis of Cr(VI) in exhaled breath condensate (EBC) and Cr in red blood cells (RBC) in addition to traditional urinary total Cr analyses. Furthermore, exposure data will be complemented with early biological effects data, including genetic and epigenetic effects. Personal air samples and wipe samples are collected in parallel to help informing the biomonitoring results. We present standard operational procedures (SOPs) to support the harmonized methodologies for the collection of occupational hygiene and HBM samples in different countries. Environ Res. 2019 Oct;177:108583. 10.1016/j.envres.2019.108583 1096-0953 Environmental Research 31330491 http://hdl.handle.net/20.500.12105/13897 Biomonitoring Effect markers Electroplating Exhaled breath condensate Hexavalent chromium Multicenter study Occupational exposure Welding Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium