2026-05-21T23:06:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/138902025-04-29T10:42:01Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Cabrerizo, Maria
author
Trallero, Gloria
author
Pena, María José
author
Cilla, Amaia
author
Megías, Gregoria
author
Muñoz-Almagro, Carmen
author
Del Amo, Eva
author
Roda, Diana
author
Mensalvas, Ana Isabel
author
Moreno-Docón, Antonio
author
García-Costa, Juan
author
Rabella, Nuria
author
Omeñaca, Manuel
author
Romero, María Pilar
author
Sanbonmatsu-Gámez, Sara
author
Pérez-Ruiz, Mercedes
author
Santos-Muñoz, María José
author
Calvo, Cristina
author
Study Group of Enterovirus and parechovirus infections in children under 3 years-old, Spain
funder
Instituto de Salud Carlos III
2022-03-29T12:25:08Z
2022-03-29T12:25:08Z
2015-11
Eur J Pediatr. 2015 Nov;174(11):1511-6.
10.1007/s00431-015-2566-9
1432-1076
European Journal of Pediatrics
25982340
http://hdl.handle.net/20.500.12105/13890
Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patients compared with those infected by enterovirus (EV). Infants <1 month with neurological or systemic symptoms were included in a multicentre prospective study. EV and HPeV detection by RT-PCR and genotyping were performed in cerebrospinal fluids (CSF), sera or throat swabs. Out of the total of 84 infants studied during 2013, 32 were EV positive (38 %) and 9 HPeV positive (11 %). HPeV-3 was identified in eight cases and HPeV-5 in one. Mean age of HPeV-positive patients was 18 days. Diagnoses were fever without source (FWS) (67 %), clinical sepsis (22 %) and encephalitis (11 %). Leukocytes in blood and CSF were normal. Pleocytosis (p = 0.03) and meningitis (p = 0.001) were significantly more frequent in patients with EV infections than with HPeV. Conclusions: Although HPeV-3 infections were detected less frequently than EV, they still account for approximately 10 % of the cases analysed in infants younger than 1 month. HPeV-3 was mainly associated with FWS and without leukocytosis and pleocytosis in CSF. In these cases, HPeV screening is desirable to identify the aetiologic agent and prevent unnecessary treatment and prolonged hospitalization.
eng
Enterovirus
Fever
Human parechovirus
Neonate
Sepsis
Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life
research article
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ComparisonOfEpidemiologyAnd_2015.pdf.txt