2026-05-22T00:36:06Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/138902025-04-29T10:42:01Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Cabrerizo, Maria author Trallero, Gloria author Pena, María José author Cilla, Amaia author Megías, Gregoria author Muñoz-Almagro, Carmen author Del Amo, Eva author Roda, Diana author Mensalvas, Ana Isabel author Moreno-Docón, Antonio author García-Costa, Juan author Rabella, Nuria author Omeñaca, Manuel author Romero, María Pilar author Sanbonmatsu-Gámez, Sara author Pérez-Ruiz, Mercedes author Santos-Muñoz, María José author Calvo, Cristina author Study Group of Enterovirus and parechovirus infections in children under 3 years-old, Spain author 2015-11 Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patients compared with those infected by enterovirus (EV). Infants <1 month with neurological or systemic symptoms were included in a multicentre prospective study. EV and HPeV detection by RT-PCR and genotyping were performed in cerebrospinal fluids (CSF), sera or throat swabs. Out of the total of 84 infants studied during 2013, 32 were EV positive (38 %) and 9 HPeV positive (11 %). HPeV-3 was identified in eight cases and HPeV-5 in one. Mean age of HPeV-positive patients was 18 days. Diagnoses were fever without source (FWS) (67 %), clinical sepsis (22 %) and encephalitis (11 %). Leukocytes in blood and CSF were normal. Pleocytosis (p = 0.03) and meningitis (p = 0.001) were significantly more frequent in patients with EV infections than with HPeV. Conclusions: Although HPeV-3 infections were detected less frequently than EV, they still account for approximately 10 % of the cases analysed in infants younger than 1 month. HPeV-3 was mainly associated with FWS and without leukocytosis and pleocytosis in CSF. In these cases, HPeV screening is desirable to identify the aetiologic agent and prevent unnecessary treatment and prolonged hospitalization. Eur J Pediatr. 2015 Nov;174(11):1511-6. 10.1007/s00431-015-2566-9 1432-1076 European Journal of Pediatrics 25982340 http://hdl.handle.net/20.500.12105/13890 Enterovirus Fever Human parechovirus Neonate Sepsis Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life