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oai:repisalud.isciii.es:20.500.12105/138892024-09-27T23:02:09Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Sebastián-Pérez, Víctor author Manoli, Maria-Tsampika author Pérez, Daniel I author Gil, Carmen author Mellado, Emilia author Martínez, Ana author Espeso, Eduardo A author Campillo, Nuria E author 2016-06 Invasive aspergillosis (IA) is one of the most severe forms of fungi infection. IA disease is mainly due to Aspergillus fumigatus, an air-borne opportunistic pathogen. Mortality rate caused by IA is still very high (50-95%), because of difficulty in early diagnostics and reduced antifungal treatment options, thus new and efficient drugs are necessary. The aim of this work is, using Aspergillus nidulans as non-pathogen model, to develop efficient drugs to treat IA. The recent discovered role of glycogen synthase kinase-3 homologue, GskA, in A. fumigatus human infection and our previous experience on human GSK-3 inhibitors focus our attention on this kinase as a target for the development of antifungal drugs. With the aim to identify effective inhibitors of colonial growth of A. fumigatus we use A. nidulans as an accurate model for in vivo and in silico studies. Several well-known human GSK-3β inhibitors were tested for inhibition of A. nidulans colony growth. Computational tools as docking studies and binding site prediction was used to explain the different biological profile of the tested inhibitors. Three of the five tested hGSK3β inhibitors are able to reduce completely the colonial growth by covalent bind to the enzyme. Therefore these compounds may be useful in different applications to eradicate IA. Eur J Med Chem. 2016 Jun 30;116:281-289. http://hdl.handle.net/20.500.12105/13889 27131621 10.1016/j.ejmech.2016.03.035 1768-3254 European Journal of Medicinal Chemistry Aspergillus nidulans Aspergillus fumigatus Fpocket GSK-3 inhibitors Docking New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth