2026-06-14T03:42:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/138612025-04-01T10:14:03Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19613
Repisalud
author
Biosca-Brull, Judit
author
Pérez-Fernández, Cristian
author
Mora, Santiago
author
Carrillo, Beatriz
author
Pinos, Helena
author
Conejo, Nelida Maria
author
Collado, Paloma
author
Arias, Jorge L
author
Martin-Sanchez, Fernando
author
Sánchez-Santed, Fernando
author
Colomina, María Teresa
funder
Ministerio de Economía y Competitividad (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2022-03-28T11:09:03Z
2022-03-28T11:09:03Z
2021-05-13
Int J Environ Res Public Health. 2021 May 13;18(10):5190.
10.3390/ijerph18105190
1660-4601
International Journal of Environmental Research And Public Health
34068255
http://hdl.handle.net/20.500.12105/13861
Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.
eng
Autism spectrum disorder
Sociability
Pesticide
Organophosphate
Carbamates
Organochlorine
Chlorpyrifos
Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models
research article
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URL
https://repisalud.isciii.es/bitstreams/34823b07-d076-4f4e-9624-fe7845426652/download
File
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RelationshipBetweenAutismSpectrum_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/021af76c-971c-46b9-b62d-1bf47ac71095/download
File
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RelationshipBetweenAutismSpectrum_2021.pdf.txt