2026-06-14T03:47:16Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/138612025-04-01T10:14:03Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19613

00925njm 22002777a 4500 dc Biosca-Brull, Judit author Pérez-Fernández, Cristian author Mora, Santiago author Carrillo, Beatriz author Pinos, Helena author Conejo, Nelida Maria author Collado, Paloma author Arias, Jorge L author Martin-Sanchez, Fernando author Sánchez-Santed, Fernando author Colomina, María Teresa author 2021-05-13 Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies. Int J Environ Res Public Health. 2021 May 13;18(10):5190. 10.3390/ijerph18105190 1660-4601 International Journal of Environmental Research And Public Health 34068255 http://hdl.handle.net/20.500.12105/13861 Autism spectrum disorder Sociability Pesticide Organophosphate Carbamates Organochlorine Chlorpyrifos Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models