2026-06-14T03:52:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/138232024-11-29T12:30:35Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16988
Repisalud
author
Martínez-Sanz, Javier
author
Jiménez, Daniel
author
Martínez-Campelo, Laura
author
Cruz, Raquel
author
Vizcarra, Pilar
author
Sánchez-Conde, Matilde
author
Ron, Raquel
author
Rodríguez, Mario
author
Herrera, Sabina
author
Moreno, Santiago
author
Lopez-Huertas, Maria Rosa
author
Serrano-Villar, Sergio
funder
Instituto de Salud Carlos III
funder
Merck, Sharp & Dohme
2022-03-25T12:56:44Z
2022-03-25T12:56:44Z
2021-12
Emerg Microbes Infect. 2021 Dec;10(1):493-496.
10.1080/22221751.2021.1902755
2222-1751
Emerging Microbes & Infections
33704002
http://hdl.handle.net/20.500.12105/13823
We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23-11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09-10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients.
eng
COVID-19
SARS-CoV-2
Genetic variants
Single-nucleotide polymorphism
Susceptibility
Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers
journal article
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URL
https://repisalud.isciii.es/bitstreams/23683dc1-65be-494b-9d64-16bb8e5a4ff8/download
File
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application/pdf
RoleOfACE2Genetic_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/2c56b5ba-49f0-414a-86cf-d34c3c3cc793/download
File
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text/plain
RoleOfACE2Genetic_2021.pdf.txt